NDUFB4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8492838	0.52	4/20
SCHEMBL8492845	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20
SCHEMBL6267768	0.55	3/20
SCHEMBL1095981	0.55	3/20
SCHEMBL4293165	0.55	3/20

Clinical trials — most relevant to NDUFB4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease	PHASE3	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	PHASE1/PHASE2	COMPLETED
Parkinson's Disease Treatment With Coenzyme Q10	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	nan	COMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
A RETROspective Study of Patients With TK2d	nan	COMPLETED
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Nicotinamide Riboside in Ulcerative Colitis	nan	RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Genetic Diagnosis in Inborn Errors of Metabolism	nan	ENROLLING_BY_INVITATION
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFB4 binder may also engage these)

Protein	Name	Similarity
Q0MQD4	—	1.000	Q0MQD4 →
Q0MQD5	—	1.000	Q0MQD5 →
P0CB71	—	1.000	P0CB71 →
P0CB72	—	1.000	P0CB72 →
P48305	—	1.000	P48305 →
Q9CQC7	—	0.999	Q9CQC7 →
C4YTL7	—	0.997	C4YTL7 →
P48306	—	0.996	P48306 →
Q86IZ2	—	0.996	Q86IZ2 →
B9WK46	—	0.996	B9WK46 →
Q6BY05	—	0.994	Q6BY05 →
A6ZPQ9	—	0.993	A6ZPQ9 →
C7GR49	—	0.993	C7GR49 →
Q3E7B2	—	0.992	Q3E7B2 →
C5E368	—	0.992	C5E368 →
Q9C0X5	—	0.992	Q9C0X5 →
P26310	—	0.992	P26310 →
Q6BL60	—	0.992	Q6BL60 →
Q22021	—	0.992	Q22021 →
Q59QC6	—	0.991	Q59QC6 →
C4YBX9	—	0.991	C4YBX9 →
Q2KP58	—	0.991	Q2KP58 →
Q9CQ91	—	0.991	Q9CQ91 →
Q9W380	—	0.991	Q9W380 →
O94705	—	0.991	O94705 →
A3LWK1	—	0.991	A3LWK1 →
C5E1G5	—	0.991	C5E1G5 →
Q54LT5	—	0.990	Q54LT5 →
C4R127	—	0.990	C4R127 →
A7TQM5	—	0.990	A7TQM5 →