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Sugi Predict / Targets / NT5M

NT5M

5'(3')-deoxyribonucleotidase, mitochondrial · Q9NPB1 · NT5M on Sugi Atlas →

331 patent compounds predicted against NT5M, 157 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL29941559 SCHEMBL29941559 0.74 2/20
SCHEMBL9216396 SCHEMBL9216396 0.59 1/20
SCHEMBL13847480 SCHEMBL13847480 0.59 1/20
SCHEMBL2455603 SCHEMBL2455603 0.53 1/20
SCHEMBL2511666 SCHEMBL2511666 0.53 1/20
SCHEMBL12303789 SCHEMBL12303789 0.53 1/20
SCHEMBL31084252 SCHEMBL31084252 0.53 1/20
SCHEMBL13939466 SCHEMBL13939466 0.51 1/20
SCHEMBL8962393 SCHEMBL8962393 0.51 1/20
SCHEMBL22992469 SCHEMBL22992469 0.51 1/20
SCHEMBL2691594 SCHEMBL2691594 0.50 1/20
SCHEMBL23650031 SCHEMBL23650031 0.49 1/20
SCHEMBL30897033 SCHEMBL30897033 0.49 1/20
SCHEMBL8591071 SCHEMBL8591071 0.49 1/20
SCHEMBL8714487 SCHEMBL8714487 0.48 1/20
SCHEMBL18202481 SCHEMBL18202481 0.48 1/20
SCHEMBL8584805 SCHEMBL8584805 0.48 1/20
SCHEMBL10239442 SCHEMBL10239442 0.48 1/20
SCHEMBL8707772 SCHEMBL8707772 0.48 1/20
Pyrophosphoric Acid Pyrophosphoric Acid (SCHEMBL1269545) 0.48 1/20

Clinical trials — most relevant to NT5M by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
th2 Modulation CRSwNP PHASE4UNKNOWN
Effect of Oxcarbazepine on Serum Brain Derived Neurotrophic Factor (BDNF) in Bipolar Disorder PHASE4COMPLETED
The Effects of Alendronate After Cure of Primary Hyperparathyroidism PHASE4WITHDRAWN
Preventing Acute Kidney Injury (AKI) in Pediatric Patients PHASE3UNKNOWN
Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study) PHASE1/PHASE2RECRUITING
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG) PHASE2ACTIVE_NOT_RECRUITING
Adenosine Signaling Modulation and Immune Checkpoint Inhibition With Hormone Sensitive Oligometastatic Prostate Cancer PHASE2RECRUITING
Hormone Therapy With or Without Definitive Radiotherapy in Metastatic Prostate Cancer PHASE2UNKNOWN
TRC105 in Adults With Advanced/Metastatic Urothelial Carcinoma PHASE2COMPLETED
A Phase 1B Dose-escalation and Phase 2a Study of Carotuximab (TRC105) in Combination With Pazopanib in Patients With Advanced Soft Tissue Sarcoma PHASE1/PHASE2COMPLETED
The Selective Personalized Radio-Immunotherapy for Locally Advanced Non-Small Cell Lung Cancer Trial 2 PHASE2NOT_YET_RECRUITING
TRC105 Combined With Standard-dose Bevacizumab for Two Patients With Metastatic And Refractory Choriocarcinoma PHASE2COMPLETED
NCT Neuro Master Match - N²M² (NOA-20) PHASE1/PHASE2COMPLETED
Study of TRC105 Combined With Standard-Dose Bevacizumab for Advanced Solid Tumors for Which Bevacizumab is Indicated PHASE1COMPLETED
A Phase 1 Study of TDM-105795 Topical Solution in Male Subjects With Androgenetic Alopecia (AGA) PHASE1COMPLETED
The Role of IL5 in Epithelial Cell Integrity EARLY_PHASE1RECRUITING
Testing Immunosuppression Threshold in Renal Allografts To Extend eGFR nanCOMPLETED
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins. nanUNKNOWN
Complement C5a Receptors in Hidradenitis Suppurativa nanCOMPLETED
Transcriptomic Responses for the Identification of Pathogens nanRECRUITING
Poor Sleep and Inflammation in HIV-Infected Adults nanCOMPLETED
Retinal Nerve Fiber Layer Thickness and Macular Thickness in Myopia, Hyperopia and Emmetropia : An OCT Study nanUNKNOWN
Evolution of Metabolic and Immune Dysfunction in In-transit Melanoma nanRECRUITING
Regular Exercise Improves Physical Capacity and Promotes Neurotrophins in Patients With Multiple Sclerosis nanCOMPLETED
Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies nanUNKNOWN
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
Study of the Effect of Antidepressant Drugs on Neurotrophic Factors in Patients With Depression nanCOMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages nanCOMPLETED
Adenosine and A2A Receptors in Human Brown Adipose Tissue nanCOMPLETED
The SeaSHeL National Prospective Cohort Study nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a NT5M binder may also engage these)

ProteinNameSimilarity
Q8VCE6 — 0.999 Q8VCE6 →
NT5C 5'(3')-deoxyribonucleotidase, cytosolic type 0.965 landscape →
Q1JQD7 — 0.958 Q1JQD7 →
O97583 — 0.957 O97583 →
Q8R2H9 — 0.956 Q8R2H9 →
PHOSPHO1 Phosphoethanolamine/phosphocholine phosphatase 0.956 landscape →
Q3UMR5 — 0.955 Q3UMR5 →
Q5ZIW1 — 0.954 Q5ZIW1 →
Q5RKZ7 — 0.953 Q5RKZ7 →
P52849 — 0.953 P52849 →
P52850 — 0.952 P52850 →
Q9DBC0 — 0.951 Q9DBC0 →
EPM2A Laforin 0.951 landscape →
Q15526 — 0.950 Q15526 →
A3KFX0 — 0.950 A3KFX0 →
MCU Calcium uniporter protein, mitochondrial 0.950 landscape →
O43272 — 0.949 O43272 →
Q6Q0N3 — 0.949 Q6Q0N3 →
Q86V88 — 0.949 Q86V88 →
LPCAT1 Lysophosphatidylcholine acyltransferase 1 0.949 landscape →
Q9R0E1 — 0.949 Q9R0E1 →
Q9BQD7 — 0.948 Q9BQD7 →
O54783 — 0.948 O54783 →
Q5R6K5 — 0.948 Q5R6K5 →
Q1M199 — 0.948 Q1M199 →
Q9NZB8 — 0.948 Q9NZB8 →
PLOD3 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 0.947 landscape →
Q6ZRP7 — 0.947 Q6ZRP7 →
Q5R5F8 — 0.946 Q5R5F8 →
Q96RR1 — 0.946 Q96RR1 →