Cholesterol

Cholesterol

SCHEMBL413494

CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OSBP P22059 6/20 1.00
RORC P51449 5/20 1.00
OSBP2 Q969R2 3/20 1.00
USP2 O75604 1/20 1.00
LMNA P02545 1/20 1.00
ABCB1 P08183 1/20 1.00
CYP46A1 Q9Y6A2 1/20 1.00
GRIN1 Q05586 6/20 0.85
GRIN2A Q12879 6/20 0.85
NR1H3 Q13133 7/20 0.84
CRYAB P02511 1/20 0.80
HMGCR P04035 1/20 0.80
ITGB3 P05106 1/20 0.80
ITGAV P06756 1/20 0.80
SREBF2 Q12772 1/20 0.80
NPC1L1 Q9UHC9 1/20 0.80
GRIN2B Q13224 5/20 0.80
DHCR24 Q15392 1/20 0.77
EPHA2 P29317 1/20 0.75
NR1H2 P55055 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cholesterol SCHEMBL21707472 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL21539517 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL22095727 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL21447271 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL23579652 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL21340667 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL23365796 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL21650234 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL23761109 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL21445079 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 398 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4301138-A2 TUMOR STORAGE AND CELL CULTURE COMPOSITIONS Iovance Biotherapeutics, Inc. (US) 2024-01-10 EP claimed
CN-117279506-A Tumor storage and cell culture compositions 艾欧凡斯生物治疗公司 2023-12-22 CN claimed
WO-2022187741-A2 TUMOR STORAGE AND CELL CULTURE COMPOSITIONS IOVANCE BIOTHERAPEUTICS, INC. (US) 2022-09-09 WO claimed
US-20260137621-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS DIASOME PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
US-20260124139-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL DIASOME PHARMACEUTICALS INC (US) 2026-05-07 US disclosed
EP-4308248-B1 COSMETIC SKIN CARE COMPOSITION UNILEVER IP HOLDINGS B V (NL) 2026-05-06 EP disclosed
US-20250387196-A1 SEGMENTAL OSCILLATION TOOL AND LUBRICANT FLORMAN MICHAEL J (US) 2025-12-25 US disclosed
EP-3503866-B1 COMPOSITIONS COMPRISING ISOHEXIDE DIESTERS OF C18 FATTY ACIDS AND THEIR USE IN METHODS FOR RESTORING EPIDERMAL INTEGRITY AND FUNCTION AND TREATING DERMATOLOGICAL DISEASES SYTHEON LTD (US) 2025-12-03 EP disclosed
EP-4251220-B1 BIOCOMPATIBLE ORGANOGEL MATRICES FOR PREPARATION OF A DRUG DELIVERY DEPOT DEPUY SYNTHES PRODUCTS INC (US) 2025-11-05 EP disclosed
US-20250288521-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS DIASOME PHARMACEUTICALS INC (US) 2025-09-18 US disclosed
US-12364430-B2 Wearable device for continuous monitoring of user health for accurate clinical outcomes and wellness programs KURANI HETAL B (US) 2025-07-22 US disclosed
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal SDG, INC. 2007-09-20 US disclosed
EP-1465933-B1 POLYMER CONJUGATES BIOCOMPATIBLES UK LTD (GB) 2007-08-29 EP disclosed
US-20070154447-A1 Linear polyethylenimine-sterol conjugates for gene delivery FURGESON DARIN Y 2007-07-05 US disclosed
EP-0954317-B1 USE OF 7 APHA-SUBSTITUTED STEROIDS TO TREAT NEUROPSYCHIATRIC DISORDERS UNIV EDINBURGH (GB) 2007-06-06 EP disclosed
US-20070116653-A1 Hair treatment compositions ACCESS BUSINESS GROUP INTERNATIONAL LLC 2007-05-24 US disclosed
US-20070088014-A1 OCULAR THERAPY USING GLUCOCORTICOID DERIVATIVES SELECTIVELY PENETRATING POSTERIOR SEGMENT TISSUES ALLERGAN, INC. (US) 2007-04-19 US disclosed
US-7183263-B2 Linear polyethylenimine-sterol conjugates for gene delivery UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2007-02-27 US disclosed
US-20070042970-A1 Folate-modified cholesterol-bearing pullulan as a drug carrier CHEMICAL SOFT R&D INC. (JP) 2007-02-22 US disclosed
US-7170575-B2 Homeotropically aligned liquid crystal layer and process for the homeotropic alignment of liquid crystals on plastic substrates MERCK PATENT GMBH (DE) 2007-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal HAVCR2, IFNAR1, MSR1 OSBP 220/4885RORC 243/4885OSBP2 496/4885
US-20070088014-A1 OCULAR THERAPY USING GLUCOCORTICOID DERIVATIVES SELECTIVELY PENETRATING POSTERIOR SEGMENT TISSUES SERPINA6, NR3C1, PDE6C OSBP 599/4885RORC 184/4885OSBP2 429/4885
US-20070042970-A1 Folate-modified cholesterol-bearing pullulan as a drug carrier CETP, EPHA2, FOLR2 OSBP 1428/4885RORC 2890/4885OSBP2 1175/4885
US-20250288521-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS FABP2, FABP1, FABP6 OSBP 209/4885RORC 3284/4885OSBP2 604/4885
US-20260137621-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS FABP2, FABP1, SGMS2 OSBP 134/4885RORC 3851/4885OSBP2 295/4885
US-20260124139-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL GPR119, INSR, FABP1 OSBP 451/4885RORC 1229/4885OSBP2 926/4885
US-20070154447-A1 Linear polyethylenimine-sterol conjugates for gene delivery LDLR, CETP, CYP11A1 OSBP 227/4885RORC 1925/4885OSBP2 103/4885
US-20070116653-A1 Hair treatment compositions CKMT1A; CKMT1B, CRAT, CPT2 OSBP 3776/4885RORC 3092/4885OSBP2 3962/4885
US-20250387196-A1 SEGMENTAL OSCILLATION TOOL AND LUBRICANT DVL1, DVL3, SHH OSBP 1923/4885RORC 2631/4885OSBP2 1324/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.