RGS19 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13516928	1.00	1/20
SCHEMBL13516931	0.86	1/20
SCHEMBL13517312	0.78	1/20
SCHEMBL13517646	0.78	1/20
SCHEMBL13517789	0.78	1/20
SCHEMBL13517395	0.76	1/20
SCHEMBL26420677	0.76	1/20
SCHEMBL13516707	0.75	1/20
SCHEMBL13517668	0.75	1/20
SCHEMBL13517716	0.75	1/20
SCHEMBL13517047	0.74	1/20
SCHEMBL13517115	0.74	1/20
SCHEMBL13517242	0.74	1/20
SCHEMBL13517756	0.74	1/20
SCHEMBL13516952	0.73	1/20
SCHEMBL13516956	0.72	1/20
SCHEMBL13516932	0.71	1/20
SCHEMBL13517061	0.70	1/20
SCHEMBL13517154	0.68	1/20
SCHEMBL13517266	0.68	1/20

Clinical trials — most relevant to RGS19 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
GSNOR Phenotyping/GSNO Challenge in Severe Asthma	EARLY_PHASE1	COMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Thrombin Regulated Platelet Activation	nan	COMPLETED
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome	nan	ACTIVE_NOT_RECRUITING
Inherited Reproductive Disorders	nan	RECRUITING
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Genetics and Psychopathology in the 22q11 Deletion Syndrome	nan	UNKNOWN
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients	nan	NOT_YET_RECRUITING
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms	nan	COMPLETED
Pathophysiology of Diabetic Gastroparesis	nan	UNKNOWN
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins	nan	COMPLETED
Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine	nan	COMPLETED
C1q/TNF-related Protein 9 (CTRP 9) Level in Preeclamptic Obese and Non-obese Pregnancies	nan	COMPLETED
The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma	nan	UNKNOWN
Modulation of Steroid Immunosuppression by Alveolar Efferocytosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RGS19 binder may also engage these)

Protein	Name	Similarity
Q9CX84	—	1.000	Q9CX84 →
O70521	—	1.000	O70521 →
Q08DC7	—	1.000	Q08DC7 →
Q9QZB0	—	1.000	Q9QZB0 →
Q9QZB1	—	1.000	Q9QZB1 →
Q9PWA1	—	0.994	Q9PWA1 →
P34295	—	0.990	P34295 →
RGS17	Regulator of G-protein signaling 17	0.989	landscape →
Q9PWA0	—	0.988	Q9PWA0 →
Q9CQE5	—	0.987	Q9CQE5 →
Q99PG4	—	0.987	Q99PG4 →
P97844	—	0.986	P97844 →
Q9NS28	—	0.986	Q9NS28 →
Q0P5H5	—	0.986	Q0P5H5 →
A3KMV8	—	0.985	A3KMV8 →
Q8CFK6	—	0.985	Q8CFK6 →
Q6VN20	—	0.985	Q6VN20 →
Q8TDY4	—	0.985	Q8TDY4 →
P49806	—	0.984	P49806 →
Q2KHW7	—	0.984	Q2KHW7 →
P56700	—	0.984	P56700 →
O75064	—	0.983	O75064 →
ARHGEF1	Rho guanine nucleotide exchange factor 1	0.983	landscape →
Q9BQI7	—	0.983	Q9BQI7 →
Q80TF6	—	0.983	Q80TF6 →
Q3S853	—	0.983	Q3S853 →
Q8K330	—	0.983	Q8K330 →
NR1H2	Oxysterols receptor LXR-beta	0.983	landscape →
O95238	—	0.982	O95238 →
D3ZEY4	—	0.982	D3ZEY4 →