Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 3/20 | 0.64 |
| ▸ | FEN1 | P39748 | 3/20 | 0.64 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.64 |
| ▸ | RNASEH1 | O60930 | 2/20 | 0.51 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15592592 | 0.74 | ERCC1 (0.68) | ERCC1FEN1ERCC4RNASEH1KDM4E | |
| SCHEMBL6656091 | 0.74 | ERCC1 (1.00) | ERCC1FEN1ERCC4 | |
| SCHEMBL13218191 | 0.74 | ERCC1 (0.76) | ERCC1FEN1ERCC4RNASEH1 | |
| SCHEMBL6884737 | 0.72 | UBE2I (0.43) | ERCC1FEN1ERCC4TMIGD3ADORA1 | |
| SCHEMBL6620626 | 0.72 | ERCC1 (0.68) | ERCC1FEN1ERCC4RNASEH1KDM4E | |
| SCHEMBL6884865 | 0.71 | ALDH1A1 (0.39) | ERCC1FEN1ERCC4TMIGD3ADORA1 | |
| SCHEMBL4157370 | 0.71 | AXL (0.46) | HSP90AA1HSP90AB1CFTRKDM4EALDH1A1 | |
| SCHEMBL6875960 | 0.70 | RNASEH1 (0.44) | ERCC1FEN1ERCC4RNASEH1TMIGD3 | |
| SCHEMBL11496775 | 0.70 | ALOX5 (0.43) | TMIGD3ADORA1KDM4EALDH1A1RAB9A | |
| SCHEMBL12697348 | 0.70 | ERCC1 (0.57) | ERCC1FEN1ERCC4RNASEH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003062211-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-07-31 | — | — | WO | disclosed |