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Sugi Predict / Targets / SLC16A8

SLC16A8

Monocarboxylate transporter 3 · O95907 · SLC16A8 on Sugi Atlas →

321 patent compounds predicted against SLC16A8, 306 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Msc-4381 Msc-4381 (SCHEMBL22116621) 1.00 1/20
Msc-4381 Msc-4381 (SCHEMBL31019750) 1.00 1/20
SCHEMBL22116778 SCHEMBL22116778 0.90 1/20
SCHEMBL22116703 SCHEMBL22116703 0.89 1/20
SCHEMBL22116501 SCHEMBL22116501 0.84 1/20
SCHEMBL22116679 SCHEMBL22116679 0.83 1/20
SCHEMBL30188226 SCHEMBL30188226 0.83 1/20
SCHEMBL22116779 SCHEMBL22116779 0.78 1/20
SCHEMBL30188311 SCHEMBL30188311 0.78 1/20
SCHEMBL30182486 SCHEMBL30182486 0.77 1/20
SCHEMBL24109639 SCHEMBL24109639 0.77 1/20
SCHEMBL22116838 SCHEMBL22116838 0.76 1/20
SCHEMBL22116531 SCHEMBL22116531 0.75 1/20
SCHEMBL22116761 SCHEMBL22116761 0.74 1/20
SCHEMBL22116629 SCHEMBL22116629 0.74 1/20
SCHEMBL30188269 SCHEMBL30188269 0.74 1/20
SCHEMBL22134858 SCHEMBL22134858 0.73 1/20
SCHEMBL22116487 SCHEMBL22116487 0.71 1/20
SCHEMBL30187879 SCHEMBL30187879 0.71 1/20
SCHEMBL22116577 SCHEMBL22116577 0.70 1/20

Clinical trials — most relevant to SLC16A8 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Genetic Basis for Variation in the Renal Elimination of Metformin PHASE4COMPLETED
Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m PHASE3COMPLETED
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome) PHASE2/PHASE3UNKNOWN
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors PHASE2ACTIVE_NOT_RECRUITING
Triac Trial II in MCT8 Deficiency Patients PHASE2ACTIVE_NOT_RECRUITING
PK Study of Oral and IV Clofarabine in High Risk Myelodysplasia+Acute Leukemias PHASE1COMPLETED
Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Interactions PHASE1COMPLETED
Evaluate the Effect of Vimseltinib on Organic Cation Transporter 2 (OCT2) PHASE1COMPLETED
Effect of Genetic Variation in the Transporter OCT2, MATE1 and MATE2-K on the PKPD of Metformin PHASE1COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters EARLY_PHASE1COMPLETED
Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I EARLY_PHASE1COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer EARLY_PHASE1UNKNOWN
Sodium Lactate Infusion in GLUT1DS Patients EARLY_PHASE1COMPLETED
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors nanUNKNOWN
Register for Patients With Thyroid Hormone Resistance. nanRECRUITING
Erythrocyte Transport of Lactate During Exercise (TELE Project) nanRECRUITING
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs nanCOMPLETED
Impact of Genetics on Metformin Pharmacokinetics nanCOMPLETED
Oxalate and Citrate in Humans - Response to Citrate nanRECRUITING
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise nanCOMPLETED
Triheptanoin (UX007) to Treat Citrate Transporter Deficiency nanNO_LONGER_AVAILABLE
Glutamate Supplementation in Young Men nanCOMPLETED
A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis nanRECRUITING
Fluorescence and Glioma Heterogeneity nanCOMPLETED
SLC13A5 Deficiency Natural History Study - Remote Only nanENROLLING_BY_INVITATION
MCT8 Deficiency Caregiver Study nanCOMPLETED
Variations in the DIO2 and MCT10 Genes and Effect of Triiodothyronine Treatment nanCOMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease nanNOT_YET_RECRUITING
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a SLC16A8 binder may also engage these)

ProteinNameSimilarity
O70461 — 0.995 O70461 →
O35308 — 0.991 O35308 →
Q6ZMD2 — 0.942 Q6ZMD2 →
Q9D232 — 0.936 Q9D232 →
Q2YDU8 — 0.934 Q2YDU8 →
Q8R0G7 — 0.933 Q8R0G7 →
Q9H2V7 — 0.930 Q9H2V7 →
Q08DX7 — 0.930 Q08DX7 →
F1NJ67 — 0.930 F1NJ67 →
F1PZV2 — 0.930 F1PZV2 →
Q96BD0 — 0.930 Q96BD0 →
Q6UXD7 — 0.929 Q6UXD7 →
Q8TF71 — 0.928 Q8TF71 →
Q6NUT3 — 0.928 Q6NUT3 →
Q3U481 — 0.928 Q3U481 →
SLC46A1 Proton-coupled folate transporter 0.927 landscape →
Q8NCK7 — 0.927 Q8NCK7 →
Q90632 — 0.926 Q90632 →
O95528 — 0.926 O95528 →
A1L1W9 — 0.926 A1L1W9 →
Q6DFR1 — 0.925 Q6DFR1 →
Q1RPP5 — 0.925 Q1RPP5 →
A0A3Q2HW92 — 0.925 A0A3Q2HW92 →
Q13286 — 0.924 Q13286 →
G5E8K6 — 0.922 G5E8K6 →
Q8VHD6 — 0.921 Q8VHD6 →
A6QLW8 — 0.921 A6QLW8 →
Q8CE47 — 0.920 Q8CE47 →
Q3U9N9 — 0.920 Q3U9N9 →
Q91Y77 — 0.920 Q91Y77 →