Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SQSTM1 | Q13501 | 4/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MMP14 | P50281 | 2/20 | 0.44 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956127 | 0.89 | MMP9 (0.46) | ALDH1A1MMP1MMP2MMP9MMP14 | |
| SCHEMBL7945733 | 0.85 | PGR (0.43) | ALDH1A1TDP1KMT2AMMP1MMP2 | |
| SCHEMBL7956113 | 0.84 | MMP1 (0.42) | ALDH1A1MEN1KMT2AMMP1MMP2 | |
| SCHEMBL7952565 | 0.82 | LMNA (0.55) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL7955839 | 0.80 | MMP2 (0.42) | ALDH1A1TDP1MAPTMMP1MMP2 | |
| SCHEMBL7955824 | 0.79 | TBXAS1 (0.42) | ALDH1A1MAPTMMP1MMP9MMP13 | |
| SCHEMBL7956055 | 0.76 | MMP2 (0.57) | ALDH1A1MEN1KMT2AMMP1MMP2 | |
| SCHEMBL7961413 | 0.76 | MMP3 (0.49) | ALDH1A1TDP1MAPTMMP2MMP9 | |
| SCHEMBL1378395 | 0.68 | MMP9 (0.42) | ALDH1A1MAPTMEN1KMT2AMMP1 | |
| SCHEMBL6688750 | 0.68 | PDE4A (0.68) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |