Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SQSTM1 | Q13501 | 3/20 | 0.70 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.70 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 7/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenetole SCHEMBL28744754 | 0.92 | SQSTM1 (0.60) | SQSTM1KEAP1NFE2L2LMNANPSR1 | |
| SCHEMBL6563645 | 0.89 | KEAP1 (0.56) | SQSTM1KEAP1NFE2L2LMNANPSR1 | |
| SCHEMBL28109026 | 0.84 | KEAP1 (0.72) | SQSTM1KEAP1NFE2L2LMNANPSR1 | |
| SCHEMBL24813021 | 0.84 | KEAP1 (0.85) | SQSTM1KEAP1NFE2L2LMNANPSR1 | |
| SCHEMBL6560643 | 0.84 | KEAP1 (0.70) | SQSTM1KEAP1NFE2L2LMNAKMT2A | |
| SCHEMBL27529515 | 0.83 | MAPT (0.51) | SQSTM1KEAP1NFE2L2LMNANPSR1 | |
| SCHEMBL5595259 | 0.81 | PGR (0.59) | KEAP1LMNAKMT2AMEN1MAPT | |
| SCHEMBL8752453 | 0.79 | KMT2A (0.91) | SQSTM1KEAP1NFE2L2LMNANPSR1 | |
| SCHEMBL398000 | 0.79 | LMNA (0.70) | KEAP1NFE2L2LMNAKMT2AMEN1 | |
| SCHEMBL30737452 | 0.78 | ALDH1A1 (0.58) | KEAP1KMT2AMEN1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990645-B1 | NOVEL SULFONAMIDE DERIVATIVES | NIPPON KAYAKU KK (JP) | 2004-07-28 | — | — | EP | disclosed |
| US-6458960-B1 | ANTICANCER AGENTS, RHEUMATIC DISEASES AND ANTIINFLAMMATORY AGENTS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2002-10-01 | — | — | US | disclosed |
| US-6180796-B1 | TUBULIN POLYMERIZATION INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0990645-A1 | NOVEL SULFONAMIDE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-04-05 | — | — | EP | disclosed |