Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | STAT3 | P40763 | 3/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.60 |
| ▸ | ELANE | P08246 | 1/20 | 0.59 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.58 |
| ▸ | TUBB | P07437 | 1/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.58 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.58 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.58 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.58 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7635979 | 0.87 | LMNA (0.65) | LMNAALDH1A1L3MBTL1TP53HPGD | |
| SCHEMBL5158052 | 0.82 | LMNA (0.79) | LMNAALDH1A1L3MBTL1TP53HPGD | |
| SCHEMBL2477690 | 0.82 | LMNA (0.70) | LMNAALDH1A1L3MBTL1TP53HPGD | |
| SCHEMBL30486834 | 0.82 | LMNA (0.70) | LMNAALDH1A1L3MBTL1TP53HPGD | |
| SCHEMBL12768028 | 0.81 | KEAP1 (0.81) | LMNAALDH1A1L3MBTL1TP53HPGD | |
| SCHEMBL4801356 | 0.81 | LMNA (0.69) | LMNAALDH1A1L3MBTL1TP53HPGD | |
| SCHEMBL2518687 | 0.81 | STAT3 (0.80) | LMNAALDH1A1L3MBTL1TP53HPGD | |
| SCHEMBL3257185 | 0.80 | KEAP1 (0.70) | LMNAALDH1A1L3MBTL1TP53HPGD | |
| SCHEMBL8626209 | 0.80 | LMNA (0.72) | LMNAALDH1A1L3MBTL1TP53HPGD | |
| SCHEMBL4953879 | 0.80 | STAT3 (0.59) | LMNAALDH1A1L3MBTL1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378427-B2 | Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines | WYETH (US) | 2008-05-27 | — | — | US | disclosed |
| US-7378427-B2 | Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines | WYETH (US) | 2008-05-27 | — | — | US | disclosed |
| US-7378427-B2 | Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines | WYETH (US) | 2008-05-27 | — | — | US | disclosed |
| EP-1758866-A1 | PROCESSES FOR PREPARING 6-ALKYL-5-ARYLSULFONYL- DIHYDROPHENANTHRIDINES | Wyeth (US) | 2007-03-07 | — | — | EP | disclosed |
| US-20060025436-A1 | Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines | WYETH (US) | 2006-02-02 | — | — | US | disclosed |
| WO-2006009831-A1 | PROCESSES FOR PREPARING 6-ALKYL-5-ARYLSULFONYL- DIHYDROPHENANTHRIDINES | WYETH (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025436-A1 | Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines | QDPR, RPS9, RPS4Y1 | LMNA 3681/4885ALDH1A1 1238/4885L3MBTL1 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.