Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30046984 | 0.92 | KDR (0.54) | RAD52SCN9ATDP1MAPK1L3MBTL1 | |
| SCHEMBL7330497 | 0.82 | RAB9A (0.74) | RAD52ADRA2AADRA2BADRA2CTDP1 | |
| SCHEMBL725063 | 0.82 | RAD52 (0.70) | RAD52ADRA2AADRA2BADRA2CTDP1 | |
| SCHEMBL23999634 | 0.80 | POLB (0.68) | KDM4ENPC1GAAMAPTMAPK1 | |
| SCHEMBL13648103 | 0.77 | SCN9A (0.51) | RAD52SCN9AADRA2AADRA2BADRA2C | |
| SCHEMBL171930 | 0.77 | SCN9A (0.47) | SCN9AADRA2AADRA2BADRA2CTDP1 | |
| SCHEMBL12218044 | 0.77 | RAD52 (0.48) | RAD52SCN9ATDP1KDM4ENPC1 | |
| SCHEMBL8540552 | 0.76 | LMNA (0.47) | SCN9ATDP1MAPTMAPK1CTSD | |
| Hydrochloric Acid SCHEMBL28541310 | 0.76 | SCN9A (0.50) | RAD52SCN9AADRA2AADRA2BADRA2C | |
| SCHEMBL13308524 | 0.75 | ALDH1A1 (0.68) | SCN9ATDP1KDM4ENPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | MKI67, DCX, NES | RAD52 839/4885SCN9A 3381/4885ADRA2A 2934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.