Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 10/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 10/20 | 0.56 |
| ▸ | GRM6 | O15303 | 5/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | KYNU | Q16719 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13774905 | 0.93 | GRM8 (0.52) | GRM8GRM4GRM6HDAC1HDAC2 | |
| SCHEMBL8239241 | 0.93 | GRM8 (0.61) | GRM8GRM4GRM6HDAC1HDAC2 | |
| SCHEMBL346780 | 0.91 | GRM8 (0.54) | GRM8GRM4GRM6HDAC1HDAC2 | |
| SCHEMBL346779 | 0.91 | GRM8 (0.54) | GRM8GRM4GRM6HDAC1HDAC2 | |
| SCHEMBL13774896 | 0.90 | GRM8 (0.53) | GRM8GRM4GRM6HDAC1HDAC2 | |
| SCHEMBL13774966 | 0.90 | GRM8 (0.53) | GRM8GRM4GRM6HDAC1HDAC2 | |
| SCHEMBL8116323 | 0.87 | KYNU (0.56) | KYNUPPARG | |
| SCHEMBL8238396 | 0.86 | GRM8 (0.56) | GRM8GRM4GRM6KYNUGSTP1 | |
| SCHEMBL13774898 | 0.86 | GRM8 (0.56) | GRM8GRM4HDAC1HDAC2KYNU | |
| SCHEMBL4085127 | 0.86 | GRM8 (0.58) | GRM8GRM4GRM6KYNUGSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120016155-A1 | DIASTEREOISOMERS OF HYPOPHOSPHOROUS ACID DERIVATIVES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-01-19 | — | — | US | disclosed |
| US-20090170813-A1 | Hypophosphorous Acid Derivatives and their Therapeutical Applications | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2009-07-02 | — | — | US | disclosed |
| US-20090170813-A1 | Hypophosphorous Acid Derivatives and their Therapeutical Applications | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170813-A1 | Hypophosphorous Acid Derivatives and their Therapeutical Applications | P4HA1, CYP2R1, EGLN3 | GRM8 1667/4885GRM4 1497/4885GRM6 1170/4885 |
| US-20120016155-A1 | DIASTEREOISOMERS OF HYPOPHOSPHOROUS ACID DERIVATIVES | PTH1R, P4HA1, FGF23 | GRM8 4160/4885GRM4 3644/4885GRM6 2596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.