Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.83 |
| ▸ | KDR | P35968 | 7/20 | 0.83 |
| ▸ | RET | P07949 | 3/20 | 0.83 |
| ▸ | BRAF | P15056 | 3/20 | 0.83 |
| ▸ | GSK3B | P49841 | 2/20 | 0.83 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.83 |
| ▸ | ABL1 | P00519 | 2/20 | 0.83 |
| ▸ | HTR1A | P08908 | 2/20 | 0.83 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.83 |
| ▸ | KIT | P10721 | 2/20 | 0.83 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.83 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.83 |
| ▸ | FLT1 | P17948 | 2/20 | 0.83 |
| ▸ | MAOA | P21397 | 2/20 | 0.83 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.83 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.83 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.83 |
| ▸ | TTK | P33981 | 2/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407209 | 0.92 | RAF1 (0.80) | RAF1KDRRETBRAFGSK3B | |
| SCHEMBL3408499 | 0.92 | RAF1 (0.83) | RAF1KDRRETBRAFGSK3B | |
| SCHEMBL28948534 | 0.92 | RAF1 (0.83) | RAF1KDRRETBRAFGSK3B | |
| SCHEMBL29793192 | 0.92 | RAF1 (0.83) | RAF1KDRRETBRAFGSK3B | |
| Sorafenib SCHEMBL29349634 | 0.91 | RAF1 (1.00) | RAF1KDRRETBRAFGSK3B | |
| SCHEMBL26158852 | 0.91 | RAF1 (0.79) | RAF1KDRRETBRAFGSK3B | |
| Sorafenib SCHEMBL8218 | 0.91 | RAF1 (1.00) | RAF1KDRRETBRAFGSK3B | |
| Sorafenib SCHEMBL14739751 | 0.91 | RAF1 (1.00) | RAF1KDRRETBRAFGSK3B | |
| SCHEMBL29918250 | 0.91 | RAF1 (1.00) | RAF1KDRRETBRAFGSK3B | |
| SCHEMBL548133 | 0.91 | RAF1 (1.00) | RAF1KDRRETBRAFGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | MEDSHINE DISCOVERY INC. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | MEDSHINE DISCOVERY INC. (CN) | 2023-05-25 | — | — | US | disclosed |
| EP-4122925-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | Medshine Discovery Inc. (CN) | 2023-01-25 | — | — | EP | disclosed |
| US-20220193242-A1 | IMMUNOPHILIN-DEPENDENT INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-06-23 | — | — | US | disclosed |
| US-10787443-B2 | RAF-degrading conjugate compounds | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-09-29 | — | — | US | disclosed |
| WO-2020163594-A1 | IMMUNOPHILIN BINDING AGENTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-08-13 | — | — | WO | disclosed |
| WO-2020163598-A1 | IMMUNOPHILIN-DEPENDENT INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-08-13 | — | — | WO | disclosed |
| US-20190183881-A1 | USE OF CDK8 INHIBITORS TO TREAT DISEASES OF INFLAMMATION AND AUTOIMMUNITY | THE BROAD INSTITUTE, INC. | 2019-06-20 | — | — | US | disclosed |
| US-9902709-B2 | Polysubstituted pyridine compound, preparation method, use and pharmaceutical composition | PEKING UNIVERSITY FOUNDER GROUP CO., LTD. (CN) | 2018-02-27 | — | — | US | disclosed |
| US-9809603-B1 | Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same | DEUTERX, LLC (US) | 2017-11-07 | — | — | US | disclosed |
| US-20120142742-A1 | OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS | BAYER HEALTHERCARE LLC (US) | 2012-06-07 | — | — | US | disclosed |
| US-20120108641-A1 | ANTITUMOR COMBINATION INCLUDING AVE8062 AND SORAFENIB | SANOFI (FR) | 2012-05-03 | — | — | US | disclosed |
| US-20120009150-A1 | DIARYL UREAS FOR TREATING VIRUS INFECTIONS | WEBER OLAF (DE) | 2012-01-12 | — | — | US | disclosed |
| US-20110263657-A1 | DIARYL UREAS FOR TREATING HEART FAILURE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-10-27 | — | — | US | disclosed |
| US-20110158942-A1 | DIARYL UREAS FOR TREATING VIRUS INFECTIONS | WEBER OLAF | 2011-06-30 | — | — | US | disclosed |
| US-20110015195-A1 | ARYL UREAS WITH ANGIOGENISIS INHIBITING ACTIVITY | DUMAS JACQUES | 2011-01-20 | — | — | US | disclosed |
| US-7838541-B2 | Aryl ureas with angiogenesis inhibiting activity | BAYER HEALTHCARE, LLC (US) | 2010-11-23 | — | — | US | disclosed |
| US-20090306020-A1 | Combination therapy comprising diaryl ureas for treating diseases | BAYER HEALTHCARE AG (DE) | 2009-12-10 | — | — | US | disclosed |
| US-20090227637-A1 | DIARYL UREAS FOR TREATING VIRUS INFECTIONS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-09-10 | — | — | US | disclosed |
| US-20090176791-A1 | Diaryl Ureas for Treating Pulmonary Hypertension | BAYER HEALTHCARE AG (DE) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220193242-A1 | IMMUNOPHILIN-DEPENDENT INHIBITORS AND USES THEREOF | CD74, CD2BP2, SERPINB1 | RAF1 3758/4885KDR 3287/4885RET 4465/4885 |
| US-20090306020-A1 | Combination therapy comprising diaryl ureas for treating diseases | CDK6, UBA6, CHUK | RAF1 845/4885KDR 1464/4885RET 300/4885 |
| US-20120009150-A1 | DIARYL UREAS FOR TREATING VIRUS INFECTIONS | UBA6, MCM6, UBQLN1 | RAF1 4258/4885KDR 3530/4885RET 2738/4885 |
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | PSMA6, PSMC1, PSMA1 | RAF1 1691/4885KDR 3355/4885RET 2858/4885 |
| US-20090176791-A1 | Diaryl Ureas for Treating Pulmonary Hypertension | UBA6, UBQLN1, UTS2R | RAF1 3995/4885KDR 2840/4885RET 3652/4885 |
| US-20110015195-A1 | ARYL UREAS WITH ANGIOGENISIS INHIBITING ACTIVITY | FLT1, FLT4, KDR | RAF1 867/4885KDR 3/4885RET 499/4885 |
| US-20190183881-A1 | USE OF CDK8 INHIBITORS TO TREAT DISEASES OF INFLAMMATION AND AUTOIMMUNITY | CDK8, CDK9, CDK6 | RAF1 525/4885KDR 3330/4885RET 2763/4885 |
| US-20120108641-A1 | ANTITUMOR COMBINATION INCLUDING AVE8062 AND SORAFENIB | TP53, AURKB, BRAF | RAF1 65/4885KDR 12/4885RET 219/4885 |
| US-20090227637-A1 | DIARYL UREAS FOR TREATING VIRUS INFECTIONS | UBA6, MCM6, UBQLN1 | RAF1 4258/4885KDR 3530/4885RET 2738/4885 |
| US-20110263657-A1 | DIARYL UREAS FOR TREATING HEART FAILURE | UBA6, UBQLN1, UHRF1 | RAF1 3510/4885KDR 4519/4885RET 4368/4885 |
| US-20110158942-A1 | DIARYL UREAS FOR TREATING VIRUS INFECTIONS | UBA6, MCM6, UBQLN1 | RAF1 4258/4885KDR 3530/4885RET 2738/4885 |
| US-10787443-B2 | RAF-degrading conjugate compounds | BRAF, RAF1, ARAF | RAF1 2/4885KDR 716/4885RET 30/4885 |
| US-20120142742-A1 | OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | RAF1 2/4885KDR 567/4885RET 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.