Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | CUL4A | Q13619 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996615 | 0.93 | CA9 (0.50) | MAPTHTTHPGDMAOAMAOB | |
| SCHEMBL997203 | 0.83 | CA9 (0.51) | MAPTHTTHPGDMAOAMAOB | |
| SCHEMBL24091291 | 0.80 | MAPT (0.60) | MAPTHTTHPGDMAOAMAOB | |
| SCHEMBL996953 | 0.80 | CA9 (0.55) | MAPTHTTHPGDMAOAMAOB | |
| SCHEMBL8035971 | 0.71 | MAOA (0.57) | MAPTHTTHPGDMAOAMAOB | |
| SCHEMBL6001543 | 0.70 | CUL4A (0.54) | MAPTHTTHPGDMAOAMAOB | |
| SCHEMBL6002101 | 0.70 | CUL4A (0.54) | MAPTHTTHPGDMAOAMAOB | |
| SCHEMBL8200836 | 0.70 | MAPT (0.53) | MAPTHTTHPGDMAOAMAOB | |
| SCHEMBL6001406 | 0.70 | MAPT (0.49) | MAPTHTTHPGDMAOAMAOB | |
| SCHEMBL8472608 | 0.69 | HTT (0.62) | MAPTHTTHPGDMAOBCA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | disclosed |