Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | MAOA | P21397 | 5/20 | 0.53 |
| ▸ | MAOB | P27338 | 5/20 | 0.53 |
| ▸ | ALPI | P09923 | 2/20 | 0.53 |
| ▸ | ALPG | P10696 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CUL4A | Q13619 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24091291 | 0.84 | MAPT (0.60) | MAPTMAOAMAOBALPIALPG | |
| SCHEMBL14030769 | 0.84 | MAOA (0.50) | MAPTMAOAMAOBALPIALPG | |
| SCHEMBL6001543 | 0.78 | CUL4A (0.54) | MAPTMAOAMAOBALPIALPG | |
| SCHEMBL6002101 | 0.78 | CUL4A (0.54) | MAPTMAOAMAOBALPIALPG | |
| SCHEMBL8035971 | 0.75 | MAOA (0.57) | MAPTMAOAMAOBALPIALPG | |
| SCHEMBL10397843 | 0.74 | MAPT (0.49) | MAPTMAOAMAOBALPIALPG | |
| SCHEMBL996615 | 0.74 | CA9 (0.50) | MAPTMAOAMAOBALPIALPG | |
| SCHEMBL8208234 | 0.70 | CUL4A (0.47) | MAPTMAOAMAOBALPIALPG | |
| SCHEMBL1000191 | 0.70 | MAPT (0.49) | MAPTMAOAMAOBALPIALPG | |
| Tioxolone SCHEMBL36433 | 0.69 | MAOA (1.00) | MAPTMAOAMAOBALPIALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110961-A | USEFUL IN PROPHYLAXIS AND TREATMENT OF MENTAL DISORDERS, SUCH AS DEPRESSION, ANXIETY | KRENITSKY PHARMACEUTICALS, INC. (US) | 2000-08-29 | — | — | US | disclosed |