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Sugi Predict / Compounds / SCHEMBL10002015

SCHEMBL10002015

SCHEMBL10002015

CC(C)(C)c1ccc(-c2cc(C3=C(c4cc(-c5ccc(C(C)(C)C)cc5)sc4-c4ccc(C(C)(C)C)cc4)C(F)(F)C(F)(F)C3(F)F)c(-c3ccc(C(C)(C)C)cc3)s2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ESR1 P03372 2/20 0.41
▸ ESR2 Q92731 2/20 0.41
▸ PRKDC P78527 1/20 0.37
▸ EP300 Q09472 8/20 0.36
▸ MAPT P10636 1/20 0.36
▸ SNCA P37840 1/20 0.36
▸ HSD17B1 P14061 2/20 0.35
▸ HSD17B2 P37059 1/20 0.35
▸ CREBBP Q92793 1/20 0.33
▸ KDM4E B2RXH2 2/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ MAPK1 P28482 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ MITF O75030 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ TP53 P04637 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ JAK2 O60674 1/20 0.31
▸ JAK1 P23458 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14838269 0.95 HSD17B1 (0.42) ESR1ESR2PRKDCEP300MAPT
SCHEMBL14838368 0.94 ESR1 (0.36) ESR1ESR2PRKDCEP300MAPT
SCHEMBL14838268 0.94 ESR1 (0.36) ESR1ESR2PRKDCEP300MAPT
SCHEMBL14838332 0.94 ESR1 (0.39) ESR1ESR2PRKDCEP300MAPT
SCHEMBL14838529 0.94 ESR1 (0.52) ESR1ESR2PRKDCEP300MAPT
SCHEMBL14838514 0.91 OPRD1 (0.39) ESR1ESR2MAPTKDM4ENPC1
SCHEMBL14838342 0.89 HDAC6 (0.41) ESR1ESR2PRKDCEP300MAPT
SCHEMBL21695432 0.88 ESR1 (0.33) ESR1ESR2PRKDCEP300
SCHEMBL9965558 0.88 EP300 (0.33) ESR1ESR2PRKDCEP300CREBBP
SCHEMBL14838520 0.88 ESR1 (0.37) ESR1ESR2PRKDCEP300MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11124524-B2 Diarylethene compounds and uses thereof SOLUTIA CANADA INC. (US) 2021-09-21 — — US disclosed
US-11079617-B2 Optical filter comprising a variable transmittance layer Solatia Canada Inc. (CA) 2021-08-03 — — US disclosed
US-10556912-B2 Diarylethene compounds and uses thereof SWITCH MATERIALS, INC. (CA) 2020-02-11 — — US disclosed
US-20190346699-A1 OPTICAL FILTER COMPRISING A VARIABLE TRANSMITTANCE LAYER SOLUTIA CANADA INC. (CA) 2019-11-14 — — US disclosed
US-10401654-B2 Optical filter comprising a variable transmittance layer SWITCH MATERIALS INC. (CA) 2019-09-03 — — US disclosed
US-20190256526-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2019-08-22 — — US disclosed
US-10254616-B2 Variable transmittance optical filter with substantially co-planar electrode system SWITCH MATERIALS, INC. (CA) 2019-04-09 — — US disclosed
US-10139695-B2 Variable transmittance optical devices SWITCH MATERIALS, INC. (CA) 2018-11-27 — — US disclosed
US-20180224677-A1 OPTICAL FILTER COMPRISING A VARIABLE TRANSMITTANCE LAYER SOLUTIA CANADA INC. (CA) 2018-08-09 — — US disclosed
US-20180224677-A1 OPTICAL FILTER COMPRISING A VARIABLE TRANSMITTANCE LAYER SOLUTIA CANADA INC. (CA) 2018-08-09 — — US disclosed
US-20130278989-A1 VARIABLE TRANSMITTANCE OPTICAL DEVICES SWITCH MATERIALS, INC. (CA) 2013-10-24 — — US disclosed
US-20130271811-A1 VARIABLE TRANSMITTANCE OPTICAL FILTER WITH SUBSTANTIALLY CO-PLANAR ELECTRODE SYSTEM SWITCH MATERIALS, INC. (CA) 2013-10-17 — — US disclosed
US-20130271811-A1 VARIABLE TRANSMITTANCE OPTICAL FILTER WITH SUBSTANTIALLY CO-PLANAR ELECTRODE SYSTEM SWITCH MATERIALS, INC. (CA) 2013-10-17 — — US disclosed
US-20130208333-A1 VARIABLE TRANSMITTANCE OPTICAL FILTER AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2013-08-15 — — US disclosed
US-20130208333-A1 VARIABLE TRANSMITTANCE OPTICAL FILTER AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2013-08-15 — — US disclosed
US-8441707-B2 Variable transmittance optical filter and uses thereof SWITCH MATERIALS, INC. (CA) 2013-05-14 — — US disclosed
US-8441707-B2 Variable transmittance optical filter and uses thereof SWITCH MATERIALS, INC. (CA) 2013-05-14 — — US disclosed
WO-2013044371-A1 PHOTOCHROMIC AND ELECTROCHROMIC DIARYLCYCLOPENTENE DERIVATIVES AS OPTICAL FILTERS SWITCH MATERIALS, INC. (CA) 2013-04-04 — — WO disclosed
US-20120044560-A9 VARIABLE TRANSMITTANCE OPTICAL FILTER AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2012-02-23 — — US disclosed
US-20100315693-A1 VARIABLE TRANSMITTANCE OPTICAL FILTER AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2010-12-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190256526-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF KCNH2, KCNH3, SCN2B ESR1 1818/4885ESR2 761/4885PRKDC 1839/4885
US-10556912-B2 Diarylethene compounds and uses thereof KCNH2, KCNH3, SCN2B ESR1 1818/4885ESR2 761/4885PRKDC 1839/4885
US-10254616-B2 Variable transmittance optical filter with substantially co-planar electrode system HCN2, HCN4, HCN1 ESR1 867/4885ESR2 1216/4885PRKDC 488/4885
US-11124524-B2 Diarylethene compounds and uses thereof KCNH2, KCNH3, SCN2B ESR1 1818/4885ESR2 761/4885PRKDC 1839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.