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SCHEMBL9965558

SCHEMBL9965558

CC(C)(C)c1ccc(Cc2sc(-c3ccc(C(C)(C)C)cc3)cc2C2=C(c3cc(-c4ccc(C(C)(C)C)cc4)sc3-c3ccc(C(C)(C)C)cc3)C(F)(F)C(F)(F)C2(F)F)cc1

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ EP300 Q09472 8/20 0.33
▸ ESR1 P03372 1/20 0.33
▸ ESR2 Q92731 1/20 0.33
▸ COPS5 Q92905 1/20 0.32
▸ PRKDC P78527 1/20 0.31
▸ CREBBP Q92793 1/20 0.30
▸ SLC5A2 P31639 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10002015 0.88 ESR1 (0.41) EP300ESR1ESR2PRKDCCREBBP
SCHEMBL10035902 0.84 ALOX5 (0.37) ESR1ESR2
SCHEMBL14838269 0.83 HSD17B1 (0.42) EP300ESR1ESR2PRKDCCREBBP
SCHEMBL14838529 0.82 ESR1 (0.52) EP300ESR1ESR2PRKDCCREBBP
SCHEMBL10036359 0.82 HSD17B1 (0.38) ESR1ESR2
SCHEMBL14838368 0.82 ESR1 (0.36) EP300ESR1ESR2PRKDCCREBBP
SCHEMBL14838332 0.82 ESR1 (0.39) EP300ESR1ESR2PRKDCCREBBP
SCHEMBL14838268 0.82 ESR1 (0.36) EP300ESR1ESR2PRKDCCREBBP
SCHEMBL14838514 0.81 OPRD1 (0.39) ESR1ESR2
SCHEMBL14838342 0.79 HDAC6 (0.41) EP300ESR1ESR2PRKDC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012079159-A1 VARIABLE TRANSMITTANCE OPTICAL DEVICES SWITCH MATERIALS INC. (CA) 2012-06-21 — — WO disclosed
US-20120044560-A9 VARIABLE TRANSMITTANCE OPTICAL FILTER AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2012-02-23 — — US disclosed
US-20100315693-A1 VARIABLE TRANSMITTANCE OPTICAL FILTER AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2010-12-16 — — US disclosed