SCHEMBL10006366

SCHEMBL10006366

N/N=C/c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.38
MAPT P10636 2/20 0.35
MAPK1 P28482 2/20 0.35
GAA P10253 2/20 0.35
KDM4E B2RXH2 2/20 0.35
RECQL P46063 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
MITF O75030 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
SCN5A Q14524 4/20 0.34
BCHE P06276 3/20 0.34
ACHE P22303 3/20 0.34
BACE1 P56817 2/20 0.34
RXRA P19793 4/20 0.34
GRIN1 Q05586 4/20 0.34
GRIN2B Q13224 4/20 0.34
TDP2 O95551 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10006369 1.00 PTGS2 (0.38) PTGS2MAPTMAPK1GAAKDM4E
SCHEMBL27860065 0.96 PTGS2 (0.36) PTGS2MAPTMAPK1GAAKDM4E
SCHEMBL27974366 0.88 PTGS2 (0.38) PTGS2MAPTMAPK1GAAKDM4E
SCHEMBL21052722 0.88 KMT2A (0.37) PTGS2MAPTMAPK1GAAKDM4E
SCHEMBL11915479 0.88 SCN5A (0.37) PTGS2MAPTMAPK1GAAKDM4E
SCHEMBL716281 0.85 KDM4E (0.39) PTGS2MAPTMAPK1GAAKDM4E
SCHEMBL27993504 0.85 GAA (0.40) PTGS2MAPTMAPK1GAAKDM4E
SCHEMBL16031017 0.84 SCN5A (0.36) PTGS2MAPTMAPK1GAAKDM4E
SCHEMBL18114755 0.84 PTGS2 (0.38) PTGS2MAPTMAPK1GAAKDM4E
SCHEMBL28831549 0.83 LMNA (0.45) GAAKDM4ENPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10590120-B2 Pesticidal compositions and methods DOW AGROSCIENCES LLC (US) 2020-03-17 US disclosed
WO-2018067764-A1 PESTICIDAL COMPOSITIONS AND METHODS DOW AGROSCIENCES LLC (US) 2018-04-12 WO disclosed
US-20180099958-A1 PESTICIDAL COMPOSITIONS AND METHODS DOW AGROSCIENCES LLC (US) 2018-04-12 US disclosed
EP-2672819-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-11-29 EP disclosed
US-20160135464-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2016-05-19 US disclosed
US-9179681-B2 Pesticidal compositions DOW AGROSCIENCES LLC (US) 2015-11-10 US disclosed
EP-2461687-B1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2015-09-16 EP disclosed
US-9107413-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2015-08-18 US disclosed
CN-103458687-B Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC 2015-06-03 CN disclosed
US-9018388-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2015-04-28 US disclosed
US-8815922-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES, LLC. (US) 2014-08-26 US disclosed
US-20140235440-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-08-21 US disclosed
US-20140206668-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-07-24 US disclosed
US-20140148340-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2014-05-29 US disclosed
US-8680269-B2 Pesticidal compositions DOW AGROSCIENCES, LLC. (US) 2014-03-25 US disclosed
CN-103458687-A Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC 2013-12-18 CN disclosed
US-20130203593-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2013-08-08 US disclosed
US-20130203592-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2013-08-08 US disclosed
US-20120202687-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC 2012-08-09 US disclosed
US-20120172217-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2012-07-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10590120-B2 Pesticidal compositions and methods ACHE, DDT, PLA2G2D PTGS2 991/4885MAPT 3752/4885MAPK1 3841/4885
US-20140148340-A1 PESTICIDAL COMPOSITIONS ACHE, DDT, PLCG2 PTGS2 726/4885MAPT 4057/4885MAPK1 4791/4885
US-20160135464-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO CYP19A1, CYP1A1, AR PTGS2 242/4885MAPT 3938/4885MAPK1 2061/4885
US-20140235440-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO CYP19A1, CYP1A1, AR PTGS2 242/4885MAPT 3938/4885MAPK1 2061/4885
US-20180099958-A1 PESTICIDAL COMPOSITIONS AND METHODS ACHE, DDT, PLA2G2D PTGS2 991/4885MAPT 3752/4885MAPK1 3841/4885
US-20120172217-A1 PESTICIDAL COMPOSITIONS DDT, AADAC, ACHE PTGS2 1600/4885MAPT 2807/4885MAPK1 4870/4885
US-20130203593-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO CYP19A1, CYP1A1, AR PTGS2 242/4885MAPT 3938/4885MAPK1 2061/4885
US-20120202687-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO CYP19A1, CYP1A1, AR PTGS2 242/4885MAPT 3938/4885MAPK1 2061/4885
US-20140206668-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO CYP19A1, CYP1A1, AR PTGS2 242/4885MAPT 3938/4885MAPK1 2061/4885
US-20130203592-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO CYP19A1, CYP1A1, AR PTGS2 242/4885MAPT 3938/4885MAPK1 2061/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.