Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MYOC | Q99972 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6900510 | 0.83 | GAA (0.48) | MAPTALDH1A1LMNAMAPK1GAA | |
| SCHEMBL7308415 | 0.81 | MGLL (0.53) | MAPTALDH1A1LMNAMAPK1GAA | |
| SCHEMBL18412616 | 0.81 | MGLL (0.53) | MAPTALDH1A1LMNAMAPK1GAA | |
| SCHEMBL15058771 | 0.79 | PPARG (0.50) | MAPTALDH1A1LMNAMAPK1NPC1 | |
| SCHEMBL7647976 | 0.79 | MAPT (0.46) | MAPTALDH1A1LMNAMAPK1NPC1 | |
| SCHEMBL23067288 | 0.79 | CA12 (0.40) | MAPTALDH1A1MAPK1GAANPC1 | |
| SCHEMBL27894878 | 0.79 | MAPT (0.55) | MAPTALDH1A1MAPK1GAANPC1 | |
| SCHEMBL11530611 | 0.79 | MAPT (0.51) | MAPTALDH1A1LMNAMAPK1RAB9A | |
| SCHEMBL31504508 | 0.78 | ALOX5 (0.51) | MAPTALDH1A1LMNAMAPK1NPC1 | |
| SCHEMBL1532248 | 0.78 | KMT2A (0.59) | MAPTALDH1A1LMNAMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423766-B | Pentane derivatives for the treatment of bacterial infections | 丹诺医药(苏州）有限公司 | 2024-05-17 | — | — | CN | disclosed |
| EP-4028404-A2 | PENAM DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | Tennor Therapeutics Limited (CN) | 2022-07-20 | — | — | EP | disclosed |
| CN-114423766-A | Penicilliane derivatives for the treatment of bacterial infections | 丹诺医药(苏州）有限公司 | 2022-04-29 | — | — | CN | disclosed |
| US-11040987-B2 | Penam derivatives for treating bacterial infections | TENNOR THERAPEUTICS LIMITED (CN) | 2021-06-22 | — | — | US | disclosed |
| WO-2021048613-A2 | PENAM DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | TENNOR THERAPEUTICS LIMITED (CN) | 2021-03-18 | — | — | WO | disclosed |
| US-20210070774-A1 | PENAM DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | TENNOR THERAPEUTICS LIMITED (CN) | 2021-03-11 | — | — | US | disclosed |
| EP-2603512-B1 | DERIVATIVES OF 6, 7-DIHYDRO-3H-OXAZOLO [3, 4-A]PYRAZINE-5, 8- DIONE | BIOLAB SANUS FARMACÊUTICA LTDA (BR) | 2015-12-30 | — | — | EP | disclosed |
| US-8338432-B2 | Derivatives of 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,9-dione as PDE-5 inhibitors | BIOLAB SANUS FARMACEUTICA LTDA. (BR) | 2012-12-25 | — | — | US | disclosed |
| US-20120040988-A1 | DERIVATIVES OF 6,7-DIHYDRO-3H-OXAZOLO[3,4-a]PYRAZINE-5,8-DIONE | BIOLAB SANUS FARMACEUTICA LTDA. (BR) | 2012-02-16 | — | — | US | disclosed |
| WO-2012019254-A1 | DERIVATIVES OF 6, 7-DIHYDRO-3H-OXAZOLO [3, 4-A] PYRAZINE-5, 8- DIONE | BIOLAB SANUS FARMACÊUTICA LTDA. (BR) | 2012-02-16 | — | — | WO | disclosed |
| CN-1762990-A | Valency platform molecules comprising aminooxy groups | JOLLA PHARMA (US) | 2006-04-26 | — | — | CN | disclosed |
| CN-1358171-A | Valency platform molecules comprising aminooxy groups | JOLLA PHARMACEUTICALS CO (US) | 2002-07-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040988-A1 | DERIVATIVES OF 6,7-DIHYDRO-3H-OXAZOLO[3,4-a]PYRAZINE-5,8-DIONE | PDE5A, PDE12, PDE3A | MAPT 2829/4885ALDH1A1 364/4885LMNA 2989/4885 |
| US-20210070774-A1 | PENAM DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | BPGM, BLVRB, PREP | MAPT 2799/4885ALDH1A1 1966/4885LMNA 1197/4885 |
| US-11040987-B2 | Penam derivatives for treating bacterial infections | BPGM, BLVRB, PREP | MAPT 2799/4885ALDH1A1 1966/4885LMNA 1197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.