Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | IDH2 | P48735 | 7/20 | 0.68 |
| ▸ | APP | P05067 | 3/20 | 0.63 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1391806 | 0.85 | MAPT (0.73) | MAPTLMNAMAPK1IDH2APP | |
| SCHEMBL30568833 | 0.81 | IDH2 (1.00) | MAPTLMNAMAPK1IDH2APP | |
| SCHEMBL4544808 | 0.79 | IDH2 (0.77) | MAPTLMNAMAPK1IDH2APP | |
| SCHEMBL1391970 | 0.79 | IDH2 (0.75) | MAPTLMNAMAPK1IDH2APP | |
| SCHEMBL15033703 | 0.78 | MAPT (0.63) | MAPTLMNAMAPK1IDH2APP | |
| SCHEMBL30933606 | 0.78 | MAPT (0.63) | MAPTLMNAMAPK1IDH2APP | |
| SCHEMBL10282670 | 0.78 | LMNA (0.63) | MAPTLMNAMAPK1IDH2APP | |
| SCHEMBL24700899 | 0.78 | IDH2 (0.75) | MAPTLMNAMAPK1IDH2APP | |
| SCHEMBL28455381 | 0.78 | IDH2 (0.91) | MAPTLMNAMAPK1IDH2APP | |
| SCHEMBL1393001 | 0.78 | LMNA (0.62) | MAPTLMNAMAPK1IDH2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140255386-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140255386-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| WO-2013019469-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | THE WISTAR INSTITUTE (US) | 2013-02-07 | — | — | WO | disclosed |
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | The Wistar Institute and North Carolina State University | 2013-01-24 | — | — | US | disclosed |
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | The Wistar Institute and North Carolina State University | 2013-01-24 | — | — | US | disclosed |
| US-20120010177-A1 | MicroRNA Modulators and Method for Identifying And Using The Same | The Wistar Institute / North Carolina State University (US) | 2012-01-12 | — | — | US | disclosed |
| US-20120010177-A1 | MicroRNA Modulators and Method for Identifying And Using The Same | The Wistar Institute / North Carolina State University (US) | 2012-01-12 | — | — | US | disclosed |
| US-20100196357-A1 | Microrna modulators and method for identifying and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-05 | — | — | US | disclosed |
| US-20100196357-A1 | Microrna modulators and method for identifying and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196357-A1 | Microrna modulators and method for identifying and using the same | AGO2, RNASE1, TRDMT1 | MAPT 4079/4885LMNA 2926/4885MAPK1 2787/4885 |
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | AGO2, RNASE1, TRDMT1 | MAPT 4079/4885LMNA 2926/4885MAPK1 2787/4885 |
| US-20120010177-A1 | MicroRNA Modulators and Method for Identifying And Using The Same | AGO2, RNASE1, TRDMT1 | MAPT 4079/4885LMNA 2926/4885MAPK1 2787/4885 |
| US-20140255386-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | AGO2, RNASE1, TRDMT1 | MAPT 4079/4885LMNA 2926/4885MAPK1 2787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.