Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | PTGES | O14684 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16832709 | 0.85 | PTGES (0.58) | DHODHALDH1A1HSD17B10PTGESALOX5 | |
| SCHEMBL26627263 | 0.83 | ESR1 (0.48) | DHODHALDH1A1HSD17B10PTGESALOX5 | |
| SCHEMBL25735933 | 0.82 | RXFP1 (0.56) | DHODHALDH1A1HSD17B10HPGDKMT2A | |
| SCHEMBL30717931 | 0.80 | DHODH (0.65) | DHODHALDH1A1HSD17B10PTGESALOX5 | |
| SCHEMBL24840868 | 0.80 | DHODH (0.65) | DHODHALDH1A1HSD17B10PTGESALOX5 | |
| SCHEMBL13343301 | 0.80 | KDM4E (0.57) | DHODHKMT2AKDM4ESMN1; SMN2POLB | |
| SCHEMBL22468804 | 0.79 | ALDH1A1 (0.67) | DHODHALDH1A1HSD17B10PTGESALOX5 | |
| SCHEMBL7399715 | 0.78 | ALDH1A1 (0.65) | DHODHALDH1A1HSD17B10PTGESALOX5 | |
| SCHEMBL11668861 | 0.78 | ALDH1A1 (0.65) | DHODHALDH1A1HSD17B10PTGESALOX5 | |
| SCHEMBL30120641 | 0.78 | ALDH1A1 (0.65) | DHODHALDH1A1HSD17B10PTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | THE BROAD INSTITUTE, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | THE BROAD INSTITUTE, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20120178749-A1 | NS1 PROTEIN INHIBITORS | ROTH MICHAEL (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120178749-A1 | NS1 PROTEIN INHIBITORS | ROTH MICHAEL (US) | 2012-07-12 | — | — | US | disclosed |
| US-8119656-B2 | Inhibitors of the influenza virus non-structural 1 protein | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-02-21 | — | — | US | disclosed |
| US-20090170840-A1 | NS1 protein inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170840-A1 | NS1 protein inhibitors | MAVS, SERPINB1, SPINT2 | DHODH 3304/4885ALDH1A1 3348/4885HSD17B10 4301/4885 |
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | COASY, JMJD7, PTMS | DHODH 539/4885ALDH1A1 1238/4885HSD17B10 527/4885 |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | ERBB2, ACP1, TK1 | DHODH 3608/4885ALDH1A1 2221/4885HSD17B10 3033/4885 |
| US-20120178749-A1 | NS1 PROTEIN INHIBITORS | MAVS, SERPINB1, SPINT2 | DHODH 3304/4885ALDH1A1 3348/4885HSD17B10 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.