Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 2/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22624721 | 0.87 | FNTA (0.57) | MAPTHTTTDP1ALDH1A1FNTA | |
| SCHEMBL10018554 | 0.86 | VCAM1 (0.51) | VCAM1AMY1AMAPTHTTTDP1 | |
| SCHEMBL10018562 | 0.81 | MAPT (0.54) | AMY1AMAPTHTTTDP1CYP1A2 | |
| SCHEMBL14642441 | 0.80 | VCAM1 (0.47) | VCAM1AMY1AMAPTHTTTDP1 | |
| SCHEMBL10018565 | 0.79 | AMY1A (0.57) | AMY1AMAPTHTTTDP1CYP1A2 | |
| SCHEMBL10018564 | 0.77 | MAPT (0.52) | AMY1AMAPTHTTTDP1CYP1A2 | |
| SCHEMBL22611881 | 0.75 | FNTA (0.57) | MAPTHTTTDP1ALDH1A1FNTA | |
| SCHEMBL14159164 | 0.75 | FNTA (0.57) | MAPTHTTTDP1ALDH1A1FNTA | |
| SCHEMBL30633412 | 0.75 | FNTA (0.57) | MAPTHTTTDP1ALDH1A1FNTA | |
| SCHEMBL13726645 | 0.74 | FNTA (0.55) | AMY1AMAPTHTTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178749-A1 | NS1 PROTEIN INHIBITORS | ROTH MICHAEL (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120178749-A1 | NS1 PROTEIN INHIBITORS | ROTH MICHAEL (US) | 2012-07-12 | — | — | US | disclosed |
| US-8119656-B2 | Inhibitors of the influenza virus non-structural 1 protein | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-02-21 | — | — | US | disclosed |
| US-8119656-B2 | Inhibitors of the influenza virus non-structural 1 protein | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-02-21 | — | — | US | disclosed |
| US-20090170840-A1 | NS1 protein inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-07-02 | — | — | US | disclosed |
| US-20090170840-A1 | NS1 protein inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170840-A1 | NS1 protein inhibitors | MAVS, SERPINB1, SPINT2 | VCAM1 526/4885AMY1A 4135/4885MAPT 2783/4885 |
| US-20120178749-A1 | NS1 PROTEIN INHIBITORS | MAVS, SERPINB1, SPINT2 | VCAM1 526/4885AMY1A 4135/4885MAPT 2783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.