Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 6/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28456093 | 0.83 | ESRRA (0.43) | ALDH1A1L3MBTL1NOTUMLMNAMAPT | |
| SCHEMBL10053486 | 0.80 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1NOTUMLMNAMAPT | |
| SCHEMBL10022371 | 0.80 | LMNA (0.51) | ALDH1A1L3MBTL1NOTUMLMNAMAPT | |
| SCHEMBL4208305 | 0.78 | NPSR1 (0.51) | ALDH1A1L3MBTL1NOTUMLMNAMAPT | |
| SCHEMBL28452133 | 0.78 | SMN1; SMN2 (0.39) | ALDH1A1L3MBTL1NOTUMLMNAMAPT | |
| SCHEMBL19836399 | 0.77 | RAB9A (0.41) | ALDH1A1NOTUMLMNAMAPTRXRA | |
| SCHEMBL18496495 | 0.77 | SMN1; SMN2 (0.65) | ALDH1A1L3MBTL1NOTUMLMNAMAPT | |
| SCHEMBL5540345 | 0.77 | LMNA (0.50) | ALDH1A1L3MBTL1NOTUMLMNAMAPT | |
| SCHEMBL3056133 | 0.77 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1NOTUMLMNAMAPT | |
| SCHEMBL5543153 | 0.77 | NOTUM (0.54) | ALDH1A1L3MBTL1NOTUMLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | ALDH1A1 2674/4885L3MBTL1 4323/4885NOTUM 3416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.