Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 9/20 | 0.43 |
| ▸ | BRD1 | O95696 | 7/20 | 0.43 |
| ▸ | BRPF3 | Q9ULD4 | 6/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10022420 | 0.87 | CDC7 (0.40) | BRPF1BRD1BRPF3BRD9CDC7 | |
| SCHEMBL12958654 | 0.85 | ENPP3 (0.39) | BRPF1BRD1BRPF3BRD9ENPP3 | |
| SCHEMBL10022436 | 0.80 | BRPF1 (0.44) | BRPF1BRD1BRPF3CYP2A6 | |
| SCHEMBL10053515 | 0.77 | BRPF1 (0.45) | BRPF1BRD1BRPF3BRD9ENPP3 | |
| SCHEMBL28265765 | 0.76 | ENPP3 (0.42) | BRPF1BRD1BRPF3BRD9ENPP3 | |
| SCHEMBL27969722 | 0.76 | ENPP3 (0.42) | BRPF1BRD1BRPF3BRD9ENPP3 | |
| SCHEMBL26745662 | 0.75 | RXFP1 (0.50) | CYP2A6KDM4EALDH1A1 | |
| SCHEMBL21730433 | 0.75 | LMNA (0.35) | BRPF1BRD1TRPA1TRIM24KDM4E | |
| SCHEMBL4617249 | 0.74 | KDM4E (0.60) | ALBTRPA1KDM4EALDH1A1EGFR | |
| SCHEMBL11689499 | 0.74 | KMT2A (0.60) | ENPP3ALBKDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | BRPF1 3073/4885BRD1 3917/4885BRPF3 2260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.