Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10167189 | 0.89 | AKT1 (0.37) | AKT1SIRT1OPRM1OPRD1OPRK1 | |
| SCHEMBL825245 | 0.86 | EPHX1 (0.39) | AKT1OPRM1OPRD1OPRK1PTGS1 | |
| SCHEMBL14542727 | 0.85 | AKT1 (0.36) | AKT1SIRT1SIRT2 | |
| SCHEMBL13499241 | 0.84 | SIRT5 (0.43) | AKT1SIRT1OPRM1OPRD1OPRK1 | |
| SCHEMBL14016183 | 0.84 | AKT1 (0.40) | AKT1SIRT1EPHX1SIRT2SIRT3 | |
| SCHEMBL11964062 | 0.83 | AKT1 (0.42) | AKT1SIRT1SIRT2SIRT3CA1 | |
| SCHEMBL14755924 | 0.81 | AKT1 (0.41) | AKT1SIRT1SIRT2SIRT3CA1 | |
| SCHEMBL327667 | 0.78 | SIRT1 (0.36) | AKT1SIRT1EPHX1SIRT2SIRT3 | |
| SCHEMBL13310414 | 0.78 | MGLL (0.50) | OPRM1OPRD1OPRK1PTGS1PTGS2 | |
| SCHEMBL13401558 | 0.77 | SIRT1 (0.33) | SIRT1EPHX1SIRT2SIRT3CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168759-B2 | Compositions monovalent for CD28 binding and methods of use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-05-01 | — | — | US | disclosed |