Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | CASP3 | P42574 | 4/20 | 0.69 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.59 |
| ▸ | FEN1 | P39748 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21067946 | 0.84 | RAB9A (0.69) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4942886 | 0.83 | ALDH1A1 (0.69) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4036255 | 0.82 | ALDH1A1 (0.73) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4987351 | 0.80 | ALDH1A1 (1.00) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL28269605 | 0.80 | ALDH1A1 (0.75) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL29352723 | 0.80 | ALDH1A1 (1.00) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL27706946 | 0.80 | ALDH1A1 (0.72) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4942987 | 0.80 | RAB9A (0.63) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL12050743 | 0.77 | S1PR4 (0.63) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL11634779 | 0.76 | ERCC5 (0.68) | RAB9ASMN1; SMN2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | ZAFGEN, INC. | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | METAP2, METAP1, ACER2 | RAB9A 3416/4885SMN1; SMN2 1171/4885MAPT 3100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.