Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.51 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941372 | 0.86 | MAPT (0.57) | MAPTPOLBSAE1UBA2ALDH1A1 | |
| SCHEMBL10061837 | 0.86 | MAPT (0.57) | MAPTPOLBSAE1UBA2ALDH1A1 | |
| SCHEMBL15924280 | 0.73 | MAPT (0.72) | MAPTPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL3256643 | 0.72 | ALDH1A1 (0.54) | MAPTPOLBSAE1UBA2ALDH1A1 | |
| SCHEMBL24122931 | 0.71 | MAPT (0.42) | MAPTPOLBSAE1UBA2ALDH1A1 | |
| SCHEMBL22015496 | 0.70 | ALDH1A1 (0.49) | MAPTPOLBSAE1UBA2ALDH1A1 | |
| SCHEMBL11649513 | 0.69 | GRM5 (0.45) | PLK1ALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL1384232 | 0.68 | MAPT (0.53) | MAPTPOLBSAE1UBA2ALDH1A1 | |
| SCHEMBL14360013 | 0.68 | MAPT (0.53) | MAPTPOLBSAE1UBA2ALDH1A1 | |
| SCHEMBL31244547 | 0.68 | L3MBTL1 (0.37) | MAPTALDH1A1KDM4ETP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | ZAFGEN, INC. | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | METAP2, METAP1, ACER2 | MAPT 3100/4885POLB 3503/4885SAE1 2241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.