Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.49 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20821559 | 0.79 | ADORA2A (0.38) | SMN1; SMN2ALDH1A1SLC9A1GAAHSD11B1 | |
| SCHEMBL27591664 | 0.78 | LMNA (0.49) | SMN1; SMN2LMNAALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL16316327 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL5544657 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1POLBSLC9A1GAA | |
| SCHEMBL12826605 | 0.74 | ALDH1A1 (0.51) | SMN1; SMN2LMNAALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL2158430 | 0.74 | NPFFR1 (0.59) | SMN1; SMN2LMNAALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL2557123 | 0.74 | LMNA (0.49) | SMN1; SMN2LMNAALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL281711 | 0.74 | ALDH1A1 (0.50) | SMN1; SMN2LMNAALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL10028052 | 0.74 | ALDH1A1 (0.62) | SMN1; SMN2ALDH1A1HSD11B1MAPTHPGD | |
| SCHEMBL13941734 | 0.74 | NPFFR1 (0.59) | SMN1; SMN2LMNAALDH1A1NPFFR1NPFFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | ZAFGEN, INC. | 2012-01-12 | — | — | US | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | METAP2, METAP1, ACER2 | SMN1; SMN2 1171/4885LMNA 4242/4885ALDH1A1 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.