SCHEMBL10028782

SCHEMBL10028782

Cc1cc(Br)cc(C(=O)N(C)C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CARM1 Q86X55 1/20 0.37
▸ DHODH Q02127 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ F10 P00742 5/20 0.36
▸ PDE4B Q07343 3/20 0.35
▸ TRPV1 Q8NER1 1/20 0.34
▸ OPRL1 P41146 1/20 0.34
▸ EDNRA P25101 1/20 0.34
▸ F2 P00734 1/20 0.34
▸ HDAC3 O15379 1/20 0.33
▸ HDAC4 P56524 1/20 0.33
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC7 Q8WUI4 1/20 0.33
▸ HDAC2 Q92769 1/20 0.33
▸ HDAC10 Q969S8 1/20 0.33
▸ HDAC11 Q96DB2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10028785 0.93 CARM1 (0.37) CARM1DHODHALDH1A1KDM4EMEN1
SCHEMBL12911819 0.92 F10 (0.38) CARM1ALDH1A1KDM4EMEN1MAPT
SCHEMBL16622518 0.91 CARM1 (0.38) CARM1DHODHALDH1A1KDM4EMEN1
SCHEMBL15244619 0.91 PDE4B (0.40) CARM1DHODHALDH1A1KDM4EMEN1
SCHEMBL11960059 0.90 F10 (0.38) CARM1DHODHALDH1A1KDM4EMEN1
SCHEMBL782214 0.90 CARM1 (0.38) CARM1DHODHALDH1A1KDM4EMEN1
SCHEMBL31059975 0.90 F10 (0.40) CARM1DHODHALDH1A1KDM4EMEN1
SCHEMBL10028765 0.89 DHODH (0.36) DHODHALDH1A1KDM4EMEN1MAPT
SCHEMBL782481 0.88 DHODH (0.36) CARM1DHODHALDH1A1KDM4EMEN1
SCHEMBL12911649 0.88 PDE4B (0.36) DHODHALDH1A1KDM4EMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1699290-B2 INSECTICIDAL ACTIVE SUBSTANCE COMBINATIONS CONTAINING ANTHRANILIC ACID AMIDES AND AT LEAST ONE OTHER INSECTICIDE BAYER CROPSCIENCE AG (DE) 2015-04-15 — — EP disclosed
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 — — US disclosed
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 — — US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 — — US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 — — US disclosed
US-8821898-B2 Active compound combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-02 — — US disclosed
US-8821898-B2 Active compound combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-02 — — US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 — — US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 — — US disclosed
US-8735431-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-05-27 — — US disclosed
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-03-20 — — US disclosed
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-03-20 — — US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 — — US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 — — US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 — — US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 — — US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 — — US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 — — US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 — — US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142327-A1 Active compound combinations having insecticidal properties ACHE, ANTXR2, NANP CARM1 1638/4885DHODH 2787/4885ALDH1A1 4054/4885
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS CARM1 3191/4885DHODH 2032/4885ALDH1A1 1621/4885
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties AADAC, ANTXR2, ACHE CARM1 2430/4885DHODH 2657/4885ALDH1A1 2314/4885
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties ACHE, CHRM3, CHRNA2 CARM1 781/4885DHODH 3666/4885ALDH1A1 2132/4885
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS CARM1 3175/4885DHODH 2064/4885ALDH1A1 1911/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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