Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726696 | 0.98 | KDM4E (0.57) | KDM4EPOLBRECQLHTTSMN1; SMN2 | |
| SCHEMBL13645489 | 0.88 | KDM4E (0.64) | KDM4EPOLBRECQLHTTSMN1; SMN2 | |
| SCHEMBL13686278 | 0.86 | KDM4E (0.62) | KDM4EPOLBRECQL | |
| Iodide SCHEMBL6263617 | 0.84 | KDM4E (0.60) | KDM4EPOLBRECQLHTTSMN1; SMN2 | |
| SCHEMBL12201138 | 0.83 | KDM4E (0.59) | KDM4EPOLBRECQLHTTSMN1; SMN2 | |
| Iodide SCHEMBL9292447 | 0.83 | KDM4E (0.61) | KDM4EPOLBRECQLHTTSMN1; SMN2 | |
| SCHEMBL12849714 | 0.82 | KDM4E (0.57) | KDM4EPOLBRECQLHTTSMN1; SMN2 | |
| SCHEMBL16450366 | 0.82 | KDM4E (0.57) | KDM4EPOLBRECQLHTTSMN1; SMN2 | |
| SCHEMBL19485776 | 0.82 | KDM4E (0.61) | KDM4EPOLBRECQLHTTSMN1; SMN2 | |
| Bromide SCHEMBL3302575 | 0.81 | KDM4E (0.56) | KDM4EPOLBRECQLHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382425-B2 | Aza-benzazolium containing cyanine dyes | Life Technologies Corporation (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150031579-A1 | Aza-Benzazolium Containing Cyanine Dyes | MOLECULAR PROBES, INC. | 2015-01-29 | — | — | US | disclosed |
| US-8883415-B2 | Aza-benzazolium containing cyanine dyes | Life Technologies Corporation (US) | 2014-11-11 | — | — | US | disclosed |
| US-20130178395-A1 | Aza-Benzazolium Containing Cyanine Dyes | Life Technologies Corporation (US) | 2013-07-11 | — | — | US | disclosed |
| US-20120295817-A1 | Aza-benzazolium Containing Cyanine Dyes | Life Technologies Corporation (US) | 2012-11-22 | — | — | US | disclosed |
| US-8252530-B2 | Aza-benzazolium containing cyanine dyes | Life Technologies Corporation (US) | 2012-08-28 | — | — | US | disclosed |
| US-20120121509-A1 | VITAL FLUOROCHROME CONJUGATES AND METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2012-05-17 | — | — | US | disclosed |
| US-20110217696-A1 | AZA-BENZAZOLIUM CONTAINING CYANINE DYES | Life Technologies Corporation (US) | 2011-09-08 | — | — | US | disclosed |
| US-7871773-B2 | nucleic acid or a poly(amino acid) samples and dyes in form of staining solution are combined for sufficient time to form dye-analyte complex and are illuminated with an appropriate wavelength whereby nucleic acid or a poly(amino acid) is detected | Life Technologies Corporation (US) | 2011-01-18 | — | — | US | disclosed |
| WO-2010141833-A2 | VITAL FLUOROCHROME CONJUGATES AND METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2010-12-09 | — | — | WO | disclosed |
| US-20080044811-A1 | nucleic acid or a poly(amino acid) samples and dyes in form of staining solution are combined for sufficient time to form dye-analyte complex and are illuminated with an appropriate wavelength whereby nucleic acid or a poly(amino acid) is detected | INVITROGEN CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
| US-7226740-B2 | nucleic acid or a poly(amino acid) samples and dyes in form of staining solution are combined for sufficient time to form dye-analyte complex and are illuminated with an appropriate wavelength whereby nucleic acid or a poly(amino acid) is detected | INVITROGEN CORPORATION (US) | 2007-06-05 | — | — | US | disclosed |
| US-20040137475-A1 | nucleic acid or a poly(amino acid) samples and dyes in form of staining solution are combined for sufficient time to form dye-analyte complex and are illuminated with an appropriate wavelength whereby nucleic acid or a poly(amino acid) is detected | Life Technologies Corporation | 2004-07-15 | — | — | US | disclosed |
| US-6664047-B1 | Assymetrical; substituted by a cationic side chain; exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or with polypeptides | MOLECULAR PROBES, INC. | 2003-12-16 | — | — | US | disclosed |
| US-6579718-B1 | For detecting and quantifying peptides, polypeptides and proteins; sensitive, facile and does not require use of organic solvents | MOLECULAR PROBES, INC. | 2003-06-17 | — | — | US | disclosed |
| WO-2000066664-A1 | AZA-BENZAZOLIUM CONTAINING CYANINE DYES | MOLECULAR PROBES, INC. (US) | 2000-11-09 | — | — | WO | disclosed |
| US-5545535-A | USING MIXTURE OF FLUORESCENT DYES | MOLECULAR PROBES, INC. (US) | 1996-08-13 | — | — | US | disclosed |
| US-5410030-A | Nucleic acid stains | MOLECULAR PROBES, INC. (US) | 1995-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040137475-A1 | nucleic acid or a poly(amino acid) samples and dyes in form of staining solution are combined for sufficient time to form dye-analyte complex and are illuminated with an appropriate wavelength whereby nucleic acid or a poly(amino acid) is detected | POLL, IK, ADAR | KDM4E 1578/4885POLB 117/4885RECQL 3518/4885 |
| US-20110217696-A1 | AZA-BENZAZOLIUM CONTAINING CYANINE DYES | AZI2, BRDT, DNMT1 | KDM4E 428/4885POLB 810/4885RECQL 2545/4885 |
| US-20120121509-A1 | VITAL FLUOROCHROME CONJUGATES AND METHODS OF USE | CASP3, CASP7, CD47 | KDM4E 3673/4885POLB 4182/4885RECQL 3128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.