Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.34 |
| ▸ | PRKACA | P17612 | 5/20 | 0.33 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10033234 | 0.90 | ALDH1A1 (0.39) | PI4KAPI4K2BPI4K2API4KBPRKACA | |
| SCHEMBL7598522 | 0.72 | PIM1 (0.50) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL4581404 | 0.65 | PI4KA (0.41) | PI4KAPI4K2BPI4K2API4KBGAA | |
| SCHEMBL10033235 | 0.61 | CA2 (0.58) | PRKACAADCY5ALDH1A1 | |
| SCHEMBL22347068 | 0.61 | APEX1 (0.38) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL986023 | 0.59 | CYP2C19 (0.56) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL29711624 | 0.59 | PI4KA (0.59) | PI4KAPI4K2BPI4K2API4KBAPEX1 | |
| SCHEMBL2179783 | 0.59 | PI4KA (0.56) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL8565 | 0.58 | ADORA2A (0.58) | PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL42336 | 0.58 | PIK3CG (0.42) | PI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158376-B2 | Bisubstrate fluorescent probe binding to protein kinases | UNIVERSITY OF TARTU (EE) | 2012-04-17 | — | — | US | disclosed |