Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 8/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 8/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 8/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42313 | 0.78 | ADORA2A (0.42) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL42336 | 0.75 | PIK3CG (0.42) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL159639 | 0.75 | ADORA2A (0.40) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL842439 | 0.75 | ADORA2A (0.40) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL12620888 | 0.75 | ADORA2A (0.40) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL8565 | 0.75 | ADORA2A (0.58) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL160304 | 0.75 | ADORA2A (0.40) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL953009 | 0.75 | NUDT1 (0.41) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL842890 | 0.75 | ADORA2A (0.40) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL843216 | 0.75 | ADORA2A (0.40) | PI4KAPI4K2BPI4K2API4KBADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070933-A1 | Purine, Pyrimidine, and Azaindole Derivatives | SERENEX, INC. | 2008-03-20 | — | — | US | claimed |
| WO-2008024981-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | claimed |
| US-20080070933-A1 | Purine, Pyrimidine, and Azaindole Derivatives | SERENEX, INC. | 2008-03-20 | — | — | US | disclosed |
| US-20080070933-A1 | Purine, Pyrimidine, and Azaindole Derivatives | SERENEX, INC. | 2008-03-20 | — | — | US | disclosed |
| US-20080070933-A1 | Purine, Pyrimidine, and Azaindole Derivatives | SERENEX, INC. | 2008-03-20 | — | — | US | disclosed |
| WO-2008024981-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070933-A1 | Purine, Pyrimidine, and Azaindole Derivatives | P2RX7, P2RX5, P2RX3 | PI4KA 2993/4885PI4K2B 3024/4885PI4K2A 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.