Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 6/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | PMM2 | O15305 | 3/20 | 0.33 |
| ▸ | MPI | P34949 | 3/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.33 |
| ▸ | G6PD | P11413 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.33 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16231302 | 0.82 | BCKDK (0.38) | CYP17A1KIF11PMM2MPIAPOBEC3G | |
| SCHEMBL22857666 | 0.81 | IDO1 (0.35) | CMA1KIF11ACHERAB9A | |
| SCHEMBL11952640 | 0.79 | ROCK1 (0.50) | CMA1PFKFB4 | |
| SCHEMBL2614663 | 0.77 | CYP17A1 (0.42) | CYP17A1CMA1CRHR1KIF11PMM2 | |
| SCHEMBL17969060 | 0.74 | CYP17A1 (0.40) | CYP17A1CMA1CRHR1KIF11PMM2 | |
| SCHEMBL545078 | 0.74 | CYP17A1 (0.40) | CYP17A1CMA1CRHR1KIF11PMM2 | |
| SCHEMBL22857665 | 0.73 | GAA (0.32) | — | |
| SCHEMBL8279309 | 0.73 | GPR3 (0.46) | NPC1RAB9A | |
| SCHEMBL29315038 | 0.73 | KIF11 (0.40) | KIF11PMM2MPIAPOBEC3GG6PD | |
| SCHEMBL4342850 | 0.72 | CMA1 (0.41) | CYP17A1CMA1PMM2MPIAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110580-B2 | Thiophene pyrazolopyrimidine compounds | ELI LILLY AND COMPANY (US) | 2012-02-07 | — | — | US | disclosed |
| US-8110580-B2 | Thiophene pyrazolopyrimidine compounds | ELI LILLY AND COMPANY (US) | 2012-02-07 | — | — | US | disclosed |
| US-7816382-B2 | Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-10-19 | — | — | US | disclosed |
| US-20100022560-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | CHEN ZHAOGEN | 2010-01-28 | — | — | US | disclosed |
| US-20070004677-A1 | Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004677-A1 | Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition | P2RY1, P2RY11, UTS2R | CYP17A1 4338/4885CMA1 1630/4885CRHR1 198/4885 |
| US-20100022560-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | CRH, CRHR1, CRHR2 | CYP17A1 589/4885CMA1 800/4885CRHR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.