Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 4/20 | 0.33 |
| ▸ | CCR8 | P51685 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CCR5 | P51681 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24132302 | 0.82 | LIMK1 (0.39) | HSP90AA1L3MBTL1NPC1LIMK1CLK1 | |
| SCHEMBL13526940 | 0.78 | LIMK1 (0.36) | HSP90AA1L3MBTL1NPC1LIMK1CLK1 | |
| SCHEMBL13763321 | 0.77 | HSP90AA1 (0.48) | HSP90AA1L3MBTL1NPC1LIMK1CLK1 | |
| SCHEMBL19699885 | 0.74 | LIMK1 (0.49) | HSP90AA1L3MBTL1NPC1LIMK1CLK1 | |
| SCHEMBL24595805 | 0.71 | NPC1 (0.42) | HSP90AA1L3MBTL1NPC1LIMK1CLK1 | |
| SCHEMBL10054253 | 0.71 | LIMK1 (0.57) | HSP90AA1L3MBTL1NPC1LIMK1CLK1 | |
| SCHEMBL20989724 | 0.70 | LIMK1 (0.45) | HSP90AA1L3MBTL1NPC1LIMK1CLK1 | |
| SCHEMBL720703 | 0.70 | HSP90AA1 (0.41) | HSP90AA1L3MBTL1NPC1LIMK1CLK1 | |
| SCHEMBL8279309 | 0.69 | GPR3 (0.46) | NPC1LMNAKDM4EMAPTTP53 | |
| SCHEMBL20041730 | 0.69 | NPC1 (0.37) | HSP90AA1L3MBTL1NPC1LIMK1CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213131-A1 | ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES | UNIVERSAL DISPLAY CORPORATION (US) | 2022-07-07 | — | — | US | disclosed |
| US-8110580-B2 | Thiophene pyrazolopyrimidine compounds | ELI LILLY AND COMPANY (US) | 2012-02-07 | — | — | US | disclosed |
| US-8110580-B2 | Thiophene pyrazolopyrimidine compounds | ELI LILLY AND COMPANY (US) | 2012-02-07 | — | — | US | disclosed |
| US-20100022560-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | CHEN ZHAOGEN | 2010-01-28 | — | — | US | disclosed |
| US-20100022560-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | CHEN ZHAOGEN | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022560-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | CRH, CRHR1, CRHR2 | HSP90AA1 1931/4885L3MBTL1 4751/4885NPC1 506/4885 |
| US-20220213131-A1 | ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES | OCIAD1, LOXL1, OCIAD2 | HSP90AA1 4516/4885L3MBTL1 1555/4885NPC1 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.