Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118738 | 0.87 | TRPV1 (0.59) | S1PR1ALDH1A1LMNAHTTPOLB | |
| SCHEMBL20460529 | 0.70 | POLB (0.60) | S1PR1ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL7044199 | 0.69 | S1PR1 (0.52) | S1PR1ALDH1A1LMNAHTTPOLB | |
| SCHEMBL8130980 | 0.69 | POLB (0.62) | S1PR1ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL10039160 | 0.68 | TRPV1 (0.55) | S1PR1POLBNPC1RAB9ATRPV1 | |
| SCHEMBL18924426 | 0.66 | L3MBTL1 (0.59) | ALDH1A1POLBNPC1RAB9AHPGD | |
| SCHEMBL2118906 | 0.65 | TRPV1 (0.82) | TRPV1 | |
| SCHEMBL27971824 | 0.65 | GPBAR1 (0.40) | ALDH1A1LMNANPC1RAB9ATRPV1 | |
| SCHEMBL10039159 | 0.64 | GABRA5 (0.48) | POLBNPC1RAB9ATRPV1GPBAR1 | |
| SCHEMBL21107100 | 0.64 | SLCO1B1 (0.50) | S1PR1ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, P2RX5 | S1PR1 2718/4885ALDH1A1 821/4885LMNA 4013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.