SCHEMBL1004

SCHEMBL1004

CCN1CC=C(c2ccccc2)O1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
HSD17B10 Q99714 3/20 0.38
ALOX15 P16050 1/20 0.38
TSHR P16473 1/20 0.38
CHRM2 P08172 3/20 0.35
CHRM4 P08173 3/20 0.35
CHRM5 P08912 3/20 0.35
CHRM1 P11229 3/20 0.35
CHRM3 P20309 3/20 0.35
KDM4E B2RXH2 3/20 0.33
KMT2A Q03164 2/20 0.33
IDO1 P14902 2/20 0.33
AGXT P21549 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
TP53 P04637 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
MAPK1 P28482 2/20 0.32
NCOA3 Q9Y6Q9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16334537 0.69 CHRM2 (0.44) ALDH1A1TSHRCHRM2CHRM4CHRM5
SCHEMBL16334152 0.67 SMN1; SMN2 (0.35) ALDH1A1ALOX15TSHRCHRM2CHRM4
SCHEMBL16333836 0.64 SLC9A1 (0.37) ALDH1A1HSD17B10TSHRSMN1; SMN2MAPK1
Biphenyl SCHEMBL323849 0.59 ALDH1A1 (0.69) ALDH1A1HSD17B10TSHRSMN1; SMN2NPC1
Biphenyl SCHEMBL27843029 0.57 MMP3 (0.61) ALDH1A1HSD17B10ALOX15TSHRKMT2A
SCHEMBL11506718 0.57 SMN1; SMN2 (0.45) ALDH1A1HSD17B10ALOX15TSHRKDM4E
Propane SCHEMBL28045232 0.57 MMP3 (0.79) ALDH1A1KMT2ASMN1; SMN2MEN1MMP3
Propane SCHEMBL10535789 0.57 MMP3 (0.79) ALDH1A1KMT2ASMN1; SMN2MEN1MMP3
Biphenyl SCHEMBL967556 0.57 ALDH1A1 (0.64) ALDH1A1HSD17B10TSHRKDM4ESMN1; SMN2
Biphenyl SCHEMBL27495409 0.56 ALDH1A1 (0.53) ALDH1A1HSD17B10SMN1; SMN2TP53MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110099682-A Coupled connector, cell binding molecule-drug conjugate containing same, and preparation and application thereof 杭州多禧生物科技有限公司 2019-08-06 CN claimed
CN-108823177-A A kind of laccase chemical modification method and its application 华南农业大学 2018-11-16 CN claimed
CN-108642023-A A kind of laccase composite modifying method and its application 华南农业大学 2018-10-12 CN claimed
CN-119838022-A Amatoxin conjugates containing branched linkers 杭州多禧生物科技有限公司 2025-04-18 CN disclosed
CN-113423430-B Amatoxin conjugates containing branched linkers 杭州多禧生物科技有限公司 2024-12-03 CN disclosed
CN-114040778-A Cell binding molecule-Tubulysin derivative conjugate and preparation method thereof 杭州多禧生物科技有限公司 2022-02-11 CN disclosed
WO-2021074898-A1 MALIC ENZYME INHIBITORS SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) 2021-04-22 WO disclosed
EP-3638676-A1 SUBSTITUTED BRIDGED DIAZEPANE DERIVATIVES AND USE THEREOF AS TASK-1 AND TASK-3 INHIBITORS Bayer Pharma Aktiengesellschaft (DE) 2020-04-22 EP disclosed
CN-110099682-A Coupled connector, cell binding molecule-drug conjugate containing same, and preparation and application thereof 杭州多禧生物科技有限公司 2019-08-06 CN disclosed
WO-2018228909-A1 SUBSTITUTED BRIDGED DIAZEPANE DERIVATIVES AND USE THEREOF AS TASK-1 AND TASK-3 INHIBITORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-12-20 WO disclosed
CN-108823177-A A kind of laccase chemical modification method and its application 华南农业大学 2018-11-16 CN disclosed
EP-0708760-A1 CYCLIC HYDRAZINE COMPOUNDS Novartis AG (CH) 1996-05-01 EP disclosed
CN-1112125-A Acyloxyhexanoic acid derivatives CIBA GEIGY AG (CH) 1995-11-22 CN disclosed
WO-1995002582-A1 CYCLIC HYDRAZINE COMPOUNDS CIBA-GEIGY AG (CH) 1995-01-26 WO disclosed
CN-1095721-A New compounds SMITHKLINE BEECHAM PLC (GB) 1994-11-30 CN disclosed
CN-1089606-A Antiretroviral acyl compounds CIBA GEIGY AG (CH) 1994-07-20 CN disclosed
CN-1023858-C Macrolide compounds AMERICAN CYANAMID CO (GB) 1994-02-23 CN disclosed
CN-1077716-A ANTIVIRAL PEPTIDES PFIZER (US) 1993-10-27 CN disclosed
CN-1050023-A The method for preparing cephalosporin derivative BEECHAM GROUP PLC (GB) 1991-03-20 CN disclosed
CN-87104431-A MACROLIDE COMPOUNDS 1987-12-30 CN disclosed