Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31474039 | 0.59 | CFTR (0.36) | SMN1; SMN2MAPK1CHRM2CHRM4CHRM5 | |
| SCHEMBL8710435 | 0.59 | LMNA (0.40) | SMN1; SMN2TSHRALDH1A1MAPTLMNA | |
| SCHEMBL23123903 | 0.59 | POLB (0.37) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Biphenyl SCHEMBL750993 | 0.59 | ALDH1A1 (0.69) | SMN1; SMN2TSHRALDH1A1MAPTL3MBTL1 | |
| Biphenyl SCHEMBL377457 | 0.59 | ALDH1A1 (0.69) | SMN1; SMN2TSHRALDH1A1MAPTL3MBTL1 | |
| Biphenyl SCHEMBL190337 | 0.59 | ALDH1A1 (0.69) | SMN1; SMN2TSHRALDH1A1MAPTL3MBTL1 | |
| Biphenyl SCHEMBL1396421 | 0.59 | ALDH1A1 (0.69) | SMN1; SMN2TSHRALDH1A1MAPTL3MBTL1 | |
| Biphenyl SCHEMBL1839538 | 0.59 | ALDH1A1 (0.69) | SMN1; SMN2TSHRALDH1A1MAPTL3MBTL1 | |
| SCHEMBL11506718 | 0.57 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPK1TSHRALDH1A1MAPT | |
| SCHEMBL25260022 | 0.57 | HSD17B3 (0.42) | SMN1; SMN2ALDH1A1MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160151335-A1 | METHODS OF MODULATING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-06-02 | — | — | US | disclosed |
| EP-3013341-A1 | METHODS OF MODULATING CFTR ACTIVITY | Proteostasis Therapeutics, Inc. (US) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014210159-A1 | METHODS OF MODULATING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2014-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160151335-A1 | METHODS OF MODULATING CFTR ACTIVITY | CFTR, HSP90B1, SERPINB1 | SMN1; SMN2 1740/4885MAPK1 3176/4885TSHR 3579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.