Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.65 |
| ▸ | MEN1 | O00255 | 8/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | PKM | P14618 | 3/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.65 |
| ▸ | CTSB | P07858 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.55 |
| ▸ | TDO2 | P48775 | 2/20 | 0.55 |
| ▸ | CASP6 | P55212 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1682758 | 0.83 | MAPT (0.69) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL6609076 | 0.81 | ALDH1A1 (0.77) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL11972798 | 0.79 | MAPT (0.62) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL17597346 | 0.79 | KMT2A (0.70) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL11973053 | 0.79 | MEN1 (0.60) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10521547 | 0.79 | ALDH1A1 (1.00) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL2111476 | 0.79 | MAPT (1.00) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL2469833 | 0.78 | ALDH1A1 (1.00) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21882146 | 0.77 | KMT2A (0.67) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL15302617 | 0.76 | TDP1 (0.50) | MAPTALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3072882-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2016-09-28 | — | — | EP | disclosed |
| EP-3072882-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2016-09-28 | — | — | EP | disclosed |
| US-8829002-B2 | Substituted methyl amines, serotonin 5-HT6 receptor antagonists, methods for production and use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2014-09-09 | — | — | US | disclosed |
| US-8829002-B2 | Substituted methyl amines, serotonin 5-HT6 receptor antagonists, methods for production and use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2014-09-09 | — | — | US | disclosed |
| US-8829002-B2 | Substituted methyl amines, serotonin 5-HT6 receptor antagonists, methods for production and use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2014-09-09 | — | — | US | disclosed |
| EP-2657225-A2 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Ivachtchenko, Alexandre Vasilievich (RU) | 2013-10-30 | — | — | EP | disclosed |
| EP-2657225-A2 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Ivachtchenko, Alexandre Vasilievich (RU) | 2013-10-30 | — | — | EP | disclosed |
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | ALLA CHEM, LLC (US) | 2013-10-10 | — | — | US | disclosed |
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | ALLA CHEM, LLC (US) | 2013-10-10 | — | — | US | disclosed |
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | ALLA CHEM, LLC (US) | 2013-10-10 | — | — | US | disclosed |
| WO-2012087182-A2 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ, ЛЛС (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | HTR6, HTR1F, HTR1A | MAPT 2227/4885ALDH1A1 2294/4885KMT2A 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.