Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15346095 | 0.91 | GAA (0.54) | HTR6GAAKDM4EALDH1A1HPGD | |
| SCHEMBL10040106 | 0.85 | HTR6 (0.67) | HTR6GAAKDM4EALDH1A1HPGD | |
| SCHEMBL1162839 | 0.81 | HTR6 (0.66) | HTR6GAAKDM4EALDH1A1HPGD | |
| SCHEMBL29480329 | 0.81 | HTR6 (0.66) | HTR6GAAKDM4EALDH1A1HPGD | |
| SCHEMBL17774701 | 0.81 | HTR6 (0.69) | HTR6GAAKDM4EALDH1A1HPGD | |
| SCHEMBL27932762 | 0.80 | MAPT (0.48) | HTR6GAAKDM4EALDH1A1HPGD | |
| SCHEMBL21300501 | 0.79 | GAA (0.64) | HTR6GAAKDM4EALDH1A1HPGD | |
| SCHEMBL9818530 | 0.79 | HTR6 (0.61) | HTR6GAAKDM4EALDH1A1HPGD | |
| SCHEMBL5258855 | 0.79 | HTR6 (0.61) | HTR6GAAKDM4EALDH1A1HPGD | |
| SCHEMBL9818432 | 0.79 | HTR6 (0.61) | HTR6GAAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3072882-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2016-09-28 | — | — | EP | disclosed |
| US-8829002-B2 | Substituted methyl amines, serotonin 5-HT6 receptor antagonists, methods for production and use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2014-09-09 | — | — | US | disclosed |
| US-8829002-B2 | Substituted methyl amines, serotonin 5-HT6 receptor antagonists, methods for production and use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2014-09-09 | — | — | US | disclosed |
| EP-2657225-A2 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Ivachtchenko, Alexandre Vasilievich (RU) | 2013-10-30 | — | — | EP | disclosed |
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | ALLA CHEM, LLC (US) | 2013-10-10 | — | — | US | disclosed |
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | ALLA CHEM, LLC (US) | 2013-10-10 | — | — | US | disclosed |
| WO-2012087182-A2 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ, ЛЛС (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | HTR6, HTR1F, HTR1A | HTR6 1/4885GAA 4856/4885KDM4E 1393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.