Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861566 | 0.85 | PTGS1 (0.51) | MAPTPOLBCA12CA9PTGDR2 | |
| SCHEMBL12299218 | 0.85 | MAPT (0.43) | MAPTPOLBCA12CA9PTGDR2 | |
| SCHEMBL12299211 | 0.85 | CA12 (0.46) | MAPTPOLBCA12CA9PTGDR2 | |
| SCHEMBL12479163 | 0.84 | CA12 (0.47) | CA12CA9PTGDR2CYP1A2CYP3A4 | |
| SCHEMBL1258872 | 0.75 | CYP1A2 (0.50) | MAPTPOLBCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL14616506 | 0.72 | PTGDR2 (0.38) | MAPTCA12CA9PTGDR2CYP1A2 | |
| SCHEMBL2543855 | 0.72 | PTGDR2 (0.41) | MAPTPOLBCA12CA9PTGDR2 | |
| SCHEMBL508733 | 0.71 | RXRA (0.49) | PTGDR2HTTLMNAPTGS1 | |
| SCHEMBL10978468 | 0.71 | KDM4E (0.43) | HTTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3749563 | 0.70 | TSHR (0.47) | PTGDR2PPARGHTTLMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451767-B1 | METHOD FOR PRODUCING (2,4-DIMETHYLBIPHENYL-3-YL) ACETIC ACIDS, ESTERS THEREOF AND INTERCONNECTIONS | BAYER CROPSCIENCE AG (DE) | 2019-08-21 | — | — | EP | disclosed |
| EP-2451767-B1 | METHOD FOR PRODUCING (2,4-DIMETHYLBIPHENYL-3-YL) ACETIC ACIDS, ESTERS THEREOF AND INTERCONNECTIONS | BAYER CROPSCIENCE AG (DE) | 2019-08-21 | — | — | EP | disclosed |
| US-9809542-B2 | Spiroheterocyclically substituted tetramic acid derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-11-07 | — | — | US | disclosed |
| EP-2534147-B1 | SPIROHETEROCYCLIC-SUBSTITUTED TETRAMIC ACID DERIVATIVES | BAYER IP GMBH (DE) | 2015-06-17 | — | — | EP | disclosed |
| US-8664428-B2 | Method for producing (2,4-dimethylbiphenyl-3-yl)acetic acids, the esters thereof and intermediate compounds | BAYER CROPSCIENCE AG (DE) | 2014-03-04 | — | — | US | disclosed |
| US-8664428-B2 | Method for producing (2,4-dimethylbiphenyl-3-yl)acetic acids, the esters thereof and intermediate compounds | BAYER CROPSCIENCE AG (DE) | 2014-03-04 | — | — | US | disclosed |
| US-8664428-B2 | Method for producing (2,4-dimethylbiphenyl-3-yl)acetic acids, the esters thereof and intermediate compounds | BAYER CROPSCIENCE AG (DE) | 2014-03-04 | — | — | US | disclosed |
| EP-2534147-A1 | SPIROHETEROCYCLICAL SUBSTITUTED TETRAMIC ACID DERIVATIVES | Bayer Intellectual Property GmbH (DE) | 2012-12-19 | — | — | EP | disclosed |
| EP-2451767-A2 | METHOD FOR PRODUCING (2,4-DIMETHYLBIPHENYL-3-YL)ACETIC ACIDS, THE ESTERS THEREOF AND INTERMEDIATE COMPOUNDS | Bayer CropScience AG (DE) | 2012-05-16 | — | — | EP | disclosed |
| US-20120116118-A1 | Method for Producing (2,4-Dimethylbiphenyl-3-yl)Acetic Acids, the Esters Thereof and Intermediate Compounds | BAYER CROPSCIENCE AG (DE) | 2012-05-10 | — | — | US | disclosed |
| US-20120116118-A1 | Method for Producing (2,4-Dimethylbiphenyl-3-yl)Acetic Acids, the Esters Thereof and Intermediate Compounds | BAYER CROPSCIENCE AG (DE) | 2012-05-10 | — | — | US | disclosed |
| US-20120116118-A1 | Method for Producing (2,4-Dimethylbiphenyl-3-yl)Acetic Acids, the Esters Thereof and Intermediate Compounds | BAYER CROPSCIENCE AG (DE) | 2012-05-10 | — | — | US | disclosed |
| US-20110230351-A1 | Spiroheterocyclically Substituted Tetramic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-09-22 | — | — | US | disclosed |
| WO-2011098443-A1 | SPIROHETEROCYCLICAL SUBSTITUTED TETRAMIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2011-08-18 | — | — | WO | disclosed |
| WO-2011003530-A2 | METHOD FOR PRODUCING (2,4-DIMETHYLBIPHENYL-3-YL)ACETIC ACIDS, THE ESTERS THEREOF AND INTERMEDIATE COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2011-01-13 | — | — | WO | disclosed |
| WO-2011003530-A2 | METHOD FOR PRODUCING (2,4-DIMETHYLBIPHENYL-3-YL)ACETIC ACIDS, THE ESTERS THEREOF AND INTERMEDIATE COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230351-A1 | Spiroheterocyclically Substituted Tetramic Acid Derivatives | AGXT, PTPRG, WIZ | MAPT 3707/4885POLB 3021/4885CA12 1458/4885 |
| US-20120116118-A1 | Method for Producing (2,4-Dimethylbiphenyl-3-yl)Acetic Acids, the Esters Thereof and Intermediate Compounds | DDC, DDT, PAH | MAPT 2238/4885POLB 1614/4885CA12 1271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.