SCHEMBL1004336

SCHEMBL1004336

CC(C)(C)[N+]([O-])=Cc1ccccc1S(=O)(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.38
ALDH1A1 P00352 3/20 0.38
MEN1 O00255 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
MYC P01106 1/20 0.37
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
ALOX15 P16050 1/20 0.33
ATIC P31939 1/20 0.33
CYP2C19 P33261 1/20 0.33
HIF1A Q16665 1/20 0.33
HSD17B10 Q99714 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
MMP1 P03956 1/20 0.33
MMP2 P08253 1/20 0.33
MMP9 P14780 1/20 0.33
MMP8 P22894 1/20 0.33
MMP13 P45452 1/20 0.33
TSHR P16473 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15216504 1.00 KMT2A (0.38) KMT2AALDH1A1MEN1TDP1MYC
SCHEMBL29514984 1.00 KMT2A (0.38) KMT2AALDH1A1MEN1TDP1MYC
SCHEMBL6449477 0.98 KMT2A (0.38) KMT2AALDH1A1MEN1TDP1MYC
SCHEMBL29136456 0.93 TDP1 (0.46) KMT2AALDH1A1MEN1TDP1MYC
SCHEMBL2799147 0.85 KMT2A (0.36) KMT2AALDH1A1MEN1TDP1TSHR
SCHEMBL13232732 0.85 KMT2A (0.36) KMT2AALDH1A1MEN1TDP1TSHR
SCHEMBL6449468 0.83 KMT2A (0.38) KMT2AALDH1A1MEN1TDP1THRB
SCHEMBL13232749 0.83 CA2 (0.40) KMT2AALDH1A1MEN1CYP2C9CA1
SCHEMBL13233049 0.82 PSIP1 (0.36) KMT2AALDH1A1MEN1TDP1CYP1A2
SCHEMBL2800278 0.82 PSIP1 (0.36) KMT2AALDH1A1MEN1TDP1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11946066-B2 RNA-based delivery systems with levels of control CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2024-04-02 US claimed
US-20230193317-A1 RNA-BASED DELIVERY SYSTEMS WITH LEVELS OF CONTROL CALIFORNIA INSTITUTE OF TECHNOLOGY 2023-06-22 US claimed
US-11453893-B2 RNA-based delivery systems with levels of control CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2022-09-27 US claimed
US-20050272724-A1 Spin trapping pharmaceutical compositions and methods for use thereof CARNEY JOHN M 2005-12-08 US claimed
US-6815425-B1 ADMINISTERED WITH N-TERT-BUTYL- ALPHA -(2-SULFOPHENYL)NITRONE (SPBN); NEUROPROTECTANTS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY 2004-11-09 US claimed
US-6339102-B1 Method and composition for treating and preventing retinal damage THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY 2002-01-15 US claimed
WO-2001028578-A2 A PHARMACEUTICAL COMPOSITION CONTAINING pGLU-GLU-PRO-NH2 AND METHOD FOR TREATING DISEASES AND INJURIES TO THE BRAIN, SPINAL CORD AND RETINA USING SAME WRAIR (US) 2001-04-26 WO claimed
WO-2000074672-A1 METHOD AND COMPOSITIONS FOR TREATING AND PREVENTING RETINAL DAMAGE DEPARTMENT OF THE ARMY, U.S. GOVERNMENT (US) 2000-12-14 WO claimed
US-5622994-A NITRONE DERIVATIVES OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) 1997-04-22 US claimed
US-20250270262-A1 METHOD FOR ROBUST CONTROL OF GENE EXPRESSION CALIFORNIA INSTITUTE OF TECHNOLOGY 2025-08-28 US disclosed
US-12297236-B2 Method for robust control of gene expression CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2025-05-13 US disclosed
US-20250134991-A1 MONOPHOSPHORYL LIPID ADJUVANT (MPLA) COMPOSITIONS, VACCINE COMPOSITIONS THEREOF, AND METHODS OF PREPARING AND USING THE SAME UNIV JEFFERSON (US) 2025-05-01 US disclosed
CN-119862602-A Data verification method, device, equipment and medium 建信金融科技有限责任公司 2025-04-22 CN disclosed
US-12269155-B2 Multivalent vaccines for rabies virus and coronaviruses THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2025-04-08 US disclosed
EP-0736004-A1 2,4-DISULFONYL PHENYL BUTYL NITRONE, ITS SALTS, AND THEIR USE AS PHARMACEUTICALS Oklahoma Medical Research Foundation (US) 1996-10-09 EP disclosed
US-5508305-A 2, 4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceuticals OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) 1996-04-16 US disclosed
US-5488145-A 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) 1996-01-30 US disclosed
US-5475032-A Treating strokes OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) 1995-12-12 US disclosed
WO-1995017876-A2 2,4-DISULPHOPHENYL BUTYLNITRONE, ITS SALTS, AND THEIR USE AS PHARMACEUTICAL SPINTRAPS OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) 1995-07-06 WO disclosed
EP-0590072-A1 USE OF SPIN TRAPPING FOR THE TREATMENT OF DISEASES ASSOCIATED WITH OXIDATION OF LIPIDS AND PROTEINS Oklahoma Medical Research Foundation (US) 1994-04-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050272724-A1 Spin trapping pharmaceutical compositions and methods for use thereof PPOX, TXN2, TXN KMT2A 4082/4885ALDH1A1 2407/4885MEN1 2645/4885
US-20250134991-A1 MONOPHOSPHORYL LIPID ADJUVANT (MPLA) COMPOSITIONS, VACCINE COMPOSITIONS THEREOF, AND METHODS OF PREPARING AND USING THE SAME SQLE, MPL, FDFT1 KMT2A 1813/4885ALDH1A1 4311/4885MEN1 317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.