Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25187742 | 0.83 | PKM (0.45) | PKMKDM4EPOLBCTDSP1TDP1 | |
| SCHEMBL8475972 | 0.83 | PKM (0.63) | PKMKDM4EPOLBCTDSP1TDP1 | |
| SCHEMBL16689288 | 0.79 | PKM (0.76) | PKMKDM4EPOLBCTDSP1TDP1 | |
| SCHEMBL7009750 | 0.79 | PKM (0.58) | PKMKDM4EPOLBCTDSP1TDP1 | |
| SCHEMBL31184710 | 0.79 | PKM (0.46) | PKMKDM4EPOLBTDP1L3MBTL1 | |
| SCHEMBL2435955 | 0.79 | TTR (0.45) | PKMKDM4EPOLBCTDSP1TDP1 | |
| SCHEMBL1056321 | 0.79 | PKM (0.46) | PKMKDM4EPOLBTDP1L3MBTL1 | |
| SCHEMBL11025037 | 0.79 | PKM (0.48) | PKMKDM4EPOLBCTDSP1TDP1 | |
| SCHEMBL31423850 | 0.78 | PKM (0.45) | PKMKDM4ETDP1TTRCDK2 | |
| SCHEMBL972269 | 0.78 | PKM (0.41) | PKMKDM4EPOLBCTDSP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682961-B2 | Quinazoline derivative | CARNA BIOSCIENCES, INC. (JP) | 2017-06-20 | — | — | US | disclosed |
| US-9682961-B2 | Quinazoline derivative | CARNA BIOSCIENCES, INC. (JP) | 2017-06-20 | — | — | US | disclosed |
| EP-3078660-A1 | NOVEL QUINAZOLINE DERIVATIVE | Carna Biosciences Inc. (JP) | 2016-10-12 | — | — | EP | disclosed |
| US-20160264555-A1 | NOVEL QUINAZOLINE DERIVATIVE | NATIONAL CANCER CENTER (JP) | 2016-09-15 | — | — | US | disclosed |
| US-20160264555-A1 | NOVEL QUINAZOLINE DERIVATIVE | NATIONAL CANCER CENTER (JP) | 2016-09-15 | — | — | US | disclosed |
| US-7863271-B2 | 2-aminobenzoxazole carboxamides as 5HT3 modulators | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-01-04 | — | — | US | disclosed |
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | AMR TECHNOLOGY, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264555-A1 | NOVEL QUINAZOLINE DERIVATIVE | WNT1, CTNNB1, CTNND1 | PKM 3946/4885KDM4E 2190/4885POLB 2859/4885 |
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | HTR3E, HTR3C, HTR3A | PKM 2714/4885KDM4E 2017/4885POLB 1879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.