Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 5/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10050013 | 0.88 | PTGER1 (0.48) | SMN1; SMN2KDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL18809058 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4ELMNASMPD1PPARD | |
| SCHEMBL547302 | 0.87 | CCR5 (0.54) | CYP1A2CCR5PTGER1LMNAHTT | |
| SCHEMBL15820919 | 0.83 | CCR5 (0.60) | SMN1; SMN2CYP1A2CCR5PTGER1LMNA | |
| SCHEMBL15270706 | 0.81 | KDM4E (0.52) | SMN1; SMN2KDM4ELMNAMTNR1AMTNR1B | |
| SCHEMBL15270663 | 0.79 | KMT2A (0.50) | SMN1; SMN2KDM4ELMNAMTNR1AMTNR1B | |
| SCHEMBL13567643 | 0.78 | LRRK2 (0.47) | SMN1; SMN2KDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL10049810 | 0.78 | CNR2 (0.54) | SMN1; SMN2CCR5PTGER1LMNAMEN1 | |
| SCHEMBL20954703 | 0.77 | MEN1 (0.51) | KDM4ELMNAMTNR1AMTNR1BPPARD | |
| SCHEMBL16306929 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4ELMNASMPD1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110601-B2 | Compound, α1 adrenergic receptor antagonistic agent, and composition | SUNTORY HOLDINGS LIMITED (JP) | 2012-02-07 | — | — | US | disclosed |
| US-20100004328-A1 | COMPOUND, Alpha1 ADRENERGIC RECEPTOR ANTAGONISTIC AGENT, AND COMPOSITION | SUNTORY HOLDING LIMITED (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-2128148-A1 | COMPOUND, ALPHA 1 ADRENALINE RECEPTOR ANTAGONIST, AND COMPOSITION | Suntory Holdings Limited (JP) | 2009-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004328-A1 | COMPOUND, Alpha1 ADRENERGIC RECEPTOR ANTAGONISTIC AGENT, AND COMPOSITION | ADRB1, ADRA1A, ADRA1D | SMN1; SMN2 4183/4885KDM4E 4637/4885CYP1A2 1250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.