Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12305112 | 0.90 | NPC1 (0.42) | ALDH1A1TP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10059591 | 0.90 | NPC1 (0.47) | ALDH1A1TP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16474843 | 0.89 | EGFR (0.53) | ALDH1A1SMN1; SMN2TOP2AF2PLG | |
| SCHEMBL16474876 | 0.88 | TOP2A (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2TOP2A | |
| SCHEMBL10059595 | 0.88 | TOP2A (0.47) | NPC1RAB9ASMN1; SMN2TOP2AF2 | |
| SCHEMBL16474832 | 0.87 | SCN2A (0.41) | ALDH1A1TP53TOP2AF2PLG | |
| SCHEMBL16474863 | 0.87 | EPHX2 (0.41) | ALDH1A1TP53SMN1; SMN2PLA2G7TOP2A | |
| SCHEMBL10059717 | 0.87 | TOP2A (0.40) | ALDH1A1TOP2AF2PLGPLAU | |
| SCHEMBL10079693 | 0.87 | ALDH1A1 (0.49) | ALDH1A1THRBTP53NPC1RAB9A | |
| SCHEMBL16474844 | 0.87 | PLAU (0.53) | ALDH1A1TOP2AF2PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120014917-A1 | METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS | UNIVERSITY OF MINNESOTA (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120014917-A1 | METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS | MMP1, MMP8, CCL11 | ALDH1A1 358/4885THRB 3672/4885TP53 2231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.