Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10079099 | 0.90 | SRC (0.44) | ALDH1A1TP53NPC1RAB9AMEN1 | |
| SCHEMBL12332996 | 0.88 | F10 (0.46) | ESRRGTRPV1TP53NPC1RAB9A | |
| SCHEMBL10079425 | 0.88 | EGFR (0.37) | ALDH1A1PLA2G7TP53POLBNPC1 | |
| SCHEMBL10059698 | 0.87 | ALDH1A1 (0.46) | ALDH1A1PLA2G7TP53POLBTHRB | |
| SCHEMBL12333101 | 0.87 | NPC1 (0.40) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL10078775 | 0.84 | PLAU (0.44) | ALDH1A1POLBNPC1RAB9AMEN1 | |
| SCHEMBL13635579 | 0.84 | ALDH1A1 (0.48) | ALDH1A1PLA2G7TP53POLBNPC1 | |
| SCHEMBL10079838 | 0.83 | ESRRG (0.43) | ALDH1A1PLA2G7ESRRGTP53POLB | |
| SCHEMBL10079691 | 0.82 | MAPT (0.55) | TRPV1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10079424 | 0.81 | RAB9A (0.45) | ALDH1A1TP53POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120014917-A1 | METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS | UNIVERSITY OF MINNESOTA (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120014917-A1 | METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS | MMP1, MMP8, CCL11 | ALDH1A1 358/4885PLA2G7 1159/4885ESRRG 1232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.