Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.72 |
| ▸ | CA9 | Q16790 | 9/20 | 0.72 |
| ▸ | CA1 | P00915 | 8/20 | 0.72 |
| ▸ | CA12 | O43570 | 3/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | CA7 | P43166 | 6/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25421518 | 0.90 | MAPT (0.82) | CA2CA9CA1CA12HDAC6 | |
| SCHEMBL25421511 | 0.90 | MAPT (0.82) | CA2CA9CA1CA12HDAC6 | |
| SCHEMBL8769257 | 0.84 | CA2 (0.65) | CA2CA9CA1CA12HDAC6 | |
| SCHEMBL31424925 | 0.83 | HDAC6 (1.00) | HDAC6ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL6881707 | 0.80 | HDAC3 (0.56) | CA2CA9CA1CA12HDAC6 | |
| SCHEMBL13569005 | 0.79 | CA2 (0.59) | CA2CA9CA1CA12ALDH1A1 | |
| SCHEMBL15850942 | 0.79 | POLB (0.80) | CA2CA9CA1HDAC6ALDH1A1 | |
| SCHEMBL15850962 | 0.79 | RAB9A (0.87) | CA2CA9CA1HDAC6ALDH1A1 | |
| SCHEMBL10026674 | 0.77 | HDAC8 (0.72) | HDAC6ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL17975139 | 0.76 | CA1 (0.56) | CA2CA9CA1CA12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2017-02-23 | — | — | US | disclosed |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2014-07-03 | — | — | US | disclosed |
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | CA2 855/4885CA9 1454/4885CA1 2849/4885 |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | CA2 855/4885CA9 1454/4885CA1 2849/4885 |
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | CA2 855/4885CA9 1454/4885CA1 2849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.