Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 12/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.67 |
| ▸ | MEN1 | O00255 | 9/20 | 0.67 |
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | POLB | P06746 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | GFER | P55789 | 4/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | MMP14 | P50281 | 3/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.63 |
| ▸ | KDM5A | P29375 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10061972 | 0.84 | GAA (0.76) | GAAKMT2AMEN1MAPTPOLB | |
| SCHEMBL11832072 | 0.79 | PTGS2 (0.68) | GAALMNAALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL31006498 | 0.79 | PTGS2 (0.68) | GAALMNAALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL5361922 | 0.78 | GAA (0.77) | GAAKMT2APOLBLMNAALDH1A1 | |
| SCHEMBL5361880 | 0.77 | HDAC1 (0.74) | GAAKMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9749208 | 0.75 | HTT (0.64) | GAAKMT2AMEN1MAPTKDM4E | |
| SCHEMBL11708176 | 0.75 | NPC1 (0.56) | GAAKMT2AMEN1KDM4ELMNA | |
| SCHEMBL10062372 | 0.74 | KDM5A (1.00) | GAAKMT2AMEN1MAPTPOLB | |
| SCHEMBL22341320 | 0.74 | FTO (0.67) | GAAKMT2AMEN1POLBKDM4E | |
| SCHEMBL5359661 | 0.72 | GAA (0.66) | GAAKMT2AMAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304206-B2 | Mass spectrometry assays for identifying compounds that activate deacetylases | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| US-8304206-B2 | Mass spectrometry assays for identifying compounds that activate deacetylases | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| EP-1853920-B1 | FLUORESCENCE POLARIZATION ASSAYS FOR ACETYLTRANSFERASE/DEACETYLASE ACTIVITY | SIRTRIS PHARMACEUTICALS INC (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20100168084-A1 | Therapeutic compounds and related methods of use | ELIXIR PHARMACEUTICALS, INC. | 2010-07-01 | — | — | US | disclosed |
| US-20100168084-A1 | Therapeutic compounds and related methods of use | ELIXIR PHARMACEUTICALS, INC. | 2010-07-01 | — | — | US | disclosed |
| US-20090221020-A1 | Mass Spectrometry Assays for Acetyltransferase/Deacetylase Activity | SIRTRIS PHARMACEUTICALS, INC (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090221020-A1 | Mass Spectrometry Assays for Acetyltransferase/Deacetylase Activity | SIRTRIS PHARMACEUTICALS, INC (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090069301-A1 | Acridine and Quinoline Derivatives as Sirtuin Modulators | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069301-A1 | Acridine and Quinoline Derivatives as Sirtuin Modulators | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-03-12 | — | — | US | disclosed |
| US-20080293081-A1 | Fluorescence Polarization Assays for Acetyltransferase/Deacetylase Activity | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293081-A1 | Fluorescence Polarization Assays for Acetyltransferase/Deacetylase Activity | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2007064902-A2 | MASS SPECTROMETRY ASSAYS FOR ACETYLTRANSFERASE/DEACETYLASE ACTIVITY | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168084-A1 | Therapeutic compounds and related methods of use | EP300, KAT2A, KAT6B | GAA 119/4885KMT2A 422/4885MEN1 2682/4885 |
| US-20090069301-A1 | Acridine and Quinoline Derivatives as Sirtuin Modulators | SIRT1, SIRT3, SIRT2 | GAA 220/4885KMT2A 1098/4885MEN1 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.