Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | F13A1 | P00488 | 3/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207760 | 0.95 | TSHR (0.57) | TSHRNPSR1KMT2AMEN1TAAR1 | |
| SCHEMBL10110930 | 0.93 | F13A1 (0.56) | TSHRNPSR1KMT2AMEN1TAAR1 | |
| SCHEMBL29636581 | 0.89 | NPSR1 (0.68) | TSHRNPSR1KMT2AMEN1TAAR1 | |
| SCHEMBL3670598 | 0.89 | NPSR1 (0.68) | TSHRNPSR1KMT2AMEN1TAAR1 | |
| SCHEMBL1454248 | 0.87 | TSHR (0.56) | TSHRNPSR1KMT2AMEN1PTGER1 | |
| SCHEMBL6847212 | 0.86 | TAAR1 (0.52) | TSHRNPSR1KMT2AMEN1TAAR1 | |
| SCHEMBL6207355 | 0.84 | F13A1 (0.53) | TSHRNPSR1KMT2AMEN1GAA | |
| SCHEMBL341990 | 0.83 | NPSR1 (0.50) | TSHRNPSR1F13A1FFAR1SMN1; SMN2 | |
| Phosphonic Acid SCHEMBL28146347 | 0.83 | NPSR1 (0.59) | TSHRNPSR1KMT2AMEN1TAAR1 | |
| SCHEMBL3925297 | 0.83 | F13A1 (0.56) | TSHRNPSR1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426273-B1 | SUBLINGUAL COMPOSITIONS COMPRISING NATURAL EXTRACTS AND USES THEREOF | HARMONIC PHARMA (FR) | 2021-04-21 | — | — | EP | disclosed |
| EP-3638203-A1 | COSMETIC COMPOSITIONS COMPRISING NATURAL EXTRACTS AND USES THEREOF | Harmonic Pharma (FR) | 2020-04-22 | — | — | EP | disclosed |
| US-20190117555-A1 | SUBLINGUAL COMPOSITIONS COMPRISING NATURAL EXTRACTS AND USES THEREOF | HARMONIC PHARMA (FR) | 2019-04-25 | — | — | US | disclosed |
| EP-3426273-A1 | SUBLINGUAL COMPOSITIONS COMPRISING NATURAL EXTRACTS AND USES THEREOF | Harmonic Pharma (FR) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017153555-A1 | SUBLINGUAL COMPOSITIONS COMPRISING NATURAL EXTRACTS AND USES THEREOF | HARMONIC PHARMA (FR) | 2017-09-14 | — | — | WO | disclosed |
| US-8633245-B2 | PAI-1 inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2014-01-21 | — | — | US | disclosed |
| EP-2272817-A1 | PAI-1 INHIBITOR | Institute of Medicinal Molecular Design, Inc. (JP) | 2011-01-12 | — | — | EP | disclosed |
| US-20090312315-A1 | PAI-1 INHIBITOR | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2009-12-17 | — | — | US | disclosed |
| US-20090131384-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS | SYNDEXA PHARMACEUTICALS CORPORATION (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131384-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS | SYNDEXA PHARMACEUTICALS CORPORATION (US) | 2009-05-21 | — | — | US | disclosed |
| WO-2007111994-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS | SYNDEXA PHARMACEUTICALS CORPORATION (US) | 2007-10-04 | — | — | WO | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
| US-5891737-A | ORTHOGONALLY PROTECTED TRIFUNCTIONAL SCAFFOLDS FOR SOLID PHASE SYNTHESIS OF PEPTIDOMIMETIC COMBINATORIAL LIBRARY | ZYMOGENETICS, INC. (US) | 1999-04-06 | — | — | US | disclosed |
| US-5646285-A | ORTHOGONALLY PROTECTED COMPOUNDS | ZYMOGENETICS, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1996040732-A1 | COMBINATORIAL NON-PEPTIDE LIBRARIES | ZYMOGENETICS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131384-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS | NR1H3, NR1H2, SREBF1 | TSHR 4546/4885NPSR1 2102/4885KMT2A 4362/4885 |
| US-20190117555-A1 | SUBLINGUAL COMPOSITIONS COMPRISING NATURAL EXTRACTS AND USES THEREOF | SHBG, GYS1, PYGM | TSHR 1756/4885NPSR1 1202/4885KMT2A 2740/4885 |
| US-20090312315-A1 | PAI-1 INHIBITOR | SERPINC1, SERPINE1, SERPINH1 | TSHR 884/4885NPSR1 3055/4885KMT2A 2586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.