Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28278468 | 0.86 | MAPT (0.51) | ARMAPTGAAHPGDALDH1A1 | |
| SCHEMBL6113125 | 0.85 | PTPN1 (0.50) | ARMAPTHPGDALDH1A1TSHR | |
| SCHEMBL29966893 | 0.85 | PTPN1 (0.50) | ARMAPTHPGDALDH1A1TSHR | |
| SCHEMBL6112852 | 0.84 | AR (0.43) | ARMAPTCES2CES1HPGD | |
| SCHEMBL6519545 | 0.82 | HPGD (0.50) | ARMAPTGAAHPGDALDH1A1 | |
| SCHEMBL17290737 | 0.81 | MEN1 (0.48) | ARMAPTHPGDALDH1A1TSHR | |
| SCHEMBL8402587 | 0.80 | LMNA (0.53) | ARMAPTGAACES2CES1 | |
| SCHEMBL6721408 | 0.80 | MAPT (0.47) | MAPTGAAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6721992 | 0.80 | PLOD2 (0.55) | ARMAPTHPGDALDH1A1TSHR | |
| SCHEMBL7988063 | 0.80 | CES2 (0.59) | MAPTGAACES2CES1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468737-A1 | SULFONE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011016470-A1 | SULFONE DERIVATIVE | 第一三共株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |