Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 3/20 | 0.55 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.46 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925141 | 0.81 | PLOD2 (0.66) | PLOD2PLOD3PLOD1TAS1R3TAS1R1 | |
| SCHEMBL17290737 | 0.81 | MEN1 (0.48) | ARTAS1R3TAS1R1MAPTALDH1A1 | |
| SCHEMBL6739948 | 0.80 | PLOD2 (0.51) | PLOD2PLOD3PLOD1ARTAS1R3 | |
| SCHEMBL10066834 | 0.80 | AR (0.40) | ARSTK17BTAS1R3TAS1R1MAPT | |
| SCHEMBL28278468 | 0.80 | MAPT (0.51) | ARMAPTALDH1A1HPGDTSHR | |
| SCHEMBL6113125 | 0.78 | PTPN1 (0.50) | ARMAPTALDH1A1HPGDTSHR | |
| SCHEMBL29966893 | 0.78 | PTPN1 (0.50) | ARMAPTALDH1A1HPGDTSHR | |
| SCHEMBL1924352 | 0.77 | PLOD2 (0.60) | PLOD2PLOD3PLOD1TAS1R3TAS1R1 | |
| SCHEMBL1924261 | 0.77 | PLOD2 (0.60) | PLOD2PLOD3PLOD1TAS1R3TAS1R1 | |
| SCHEMBL4029594 | 0.77 | HTT (0.58) | PLOD2PLOD3PLOD1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040092552-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | PHARMACIA CORPORATION | 2004-05-13 | — | — | US | disclosed |
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020183362-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | PHARMACIA CORPORATION | 2002-12-05 | — | — | US | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |
| WO-1999025695-A1 | 5-ARYLPYRAZOLE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183362-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | FPR2, FPR1, PTGES2 | PLOD2 2953/4885PLOD3 4109/4885PLOD1 3066/4885 |
| US-20040092552-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | FPR2, PTGES2, FPR1 | PLOD2 2913/4885PLOD3 3985/4885PLOD1 3083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.