Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14286155 | 0.83 | NPC1 (0.53) | RAB9ANPC1ALDH1A1HPGDKDM4E | |
| SCHEMBL10067975 | 0.80 | ALDH1A1 (0.46) | RAB9ANPC1ALDH1A1HPGDKDM4E | |
| SCHEMBL10067395 | 0.75 | GSK3B (0.49) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10067970 | 0.74 | PTGES (0.39) | RAB9ANPC1ALDH1A1LMNAPOLB | |
| SCHEMBL14278771 | 0.72 | MAPK1 (0.49) | RAB9ANPC1ALDH1A1HPGDKDM4E | |
| SCHEMBL14600777 | 0.72 | GSK3B (0.53) | RAB9ANPC1ALDH1A1HPGDKDM4E | |
| SCHEMBL14600753 | 0.71 | GSK3B (0.53) | RAB9ANPC1ALDH1A1HPGDKDM4E | |
| SCHEMBL10067976 | 0.70 | GSK3B (0.44) | RAB9ANPC1ALDH1A1HPGDMEN1 | |
| SCHEMBL14600774 | 0.70 | GSK3B (0.45) | RAB9ANPC1ALDH1A1HPGDKDM4E | |
| SCHEMBL14600779 | 0.69 | MEN1 (0.46) | RAB9ANPC1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697352-B1 | 4-AZOLE SUBSTITUTED IMIDAZOLE COMPOSITIONS USEFUL AS INHIBITORS OR C-MET RECEPTOR TYROSINE KINASE | VERTEX PHARMA (US) | 2012-06-27 | — | — | EP | disclosed |
| US-7169800-B2 | Imidazole compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-01-30 | — | — | US | disclosed |